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This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.

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Selected publications from March 2025

This month’s publications show how PacBio HiFi sequencing is being used to address complex problems in clinical genetics, brain research, and crop development. The March 2025 edition of our…

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Inspiring the next generation of scientists: How multidisciplinary science powers PacBio technology

PacBio is hitting the pavement this weekend for the Seq It Forward 5K + Fun Run, backing San Diego LabRats and hands-on STEM education. Science starts young, and this event…

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2024 SMRT Conserve grant winners

At PacBio, we see genomics as a powerful way to help protect Earth’s biodiversity. Around the world, researchers are working to sequence tens of thousands of species, gaining insights…

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Selected publications from February 2025

HiFi sequencing continues to drive discoveries across research areas, from chromatin architecture to immune system diversity and gene therapy safety. In the February 2025 edition of Powered by PacBio,…

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Rare Disease Month: Putting People First

As February comes to a close, we approach Rare Disease Day on February 28 and reflect on the purpose behind our work in rare disease research. At PacBio, our…

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How HiFi sequencing is making a difference for rare disease research at Children’s Mercy

A rare disease can be an immense burden on patients and families, especially when it comes to childhood conditions. The path from symptoms to diagnosis to treatment is often…

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How HiFi sequencing lays the groundwork for accelerating rare disease diagnostics in the clinic

In February we are observing Rare Disease Month, a time to shine a light on the experiences of rare disease patients and their families. At PacBio, we are committed…

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Selected publications from January 2025

The start of 2025 is proving to be an influential moment for long-read sequencing, with a surge of research showcasing the power of PacBio HiFi sequencing. This month, we’re…

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Sequencing 101: Epigenetics

Epigenetics is all about understanding how gene activity can change without altering the DNA sequence itself. Think of it as a “volume control” for your genes, turning them up…

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Publication spotlight: Advancing plant breeding with long-read low-pass sequencing

We are energized from celebrating a Bright New Day at PAG last week! We had a fantastic time connecting with the plant and animal genomics community through collaborative discussions…

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New Ampli-Fi ultra-low-input protocol will support HiFi sequencing from as little as 1 ng of DNA

Highly accurate long-read sequencing technologies have made it possible to generate genome assemblies at scale. In fact, HiFi sequencing is now the technology of choice for assembling reference-quality genomes…

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PacBio 2024 Wrapped: A year of breakthroughs by the numbers

Onso short-read sequencing systems are no longer available through PacBio As we welcome a new year, we’re energized by what’s ahead—because of what we’ve accomplished together. 2024 was a…

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Selected publications from December 2024

As we close out 2024, the power of PacBio technology has never been more evident. December brought an inspiring array of research that highlights how HiFi sequencing is driving…

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A father’s journey: finding hope through genomics

In Austin, Texas, Casey McPherson balances many roles—musician, entrepreneur, and most importantly, dad to his two daughters, Weston and Rose. But beneath the day-to-day rhythms of family life lies…

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Garvan Institute researchers demonstrate that saliva samples are viable for long-read sequencing

Population studies, direct-to-consumer genetic tests, biobanks, and other large-scale genomic research projects rely on DNA gathered from saliva samples, which are often self-collected and submitted by the general public….

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