Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
How HiFi sequencing is making a difference for rare disease research at Children’s Mercy
A rare disease can be an immense burden on patients and families, especially when it comes to childhood conditions. The path from symptoms to diagnosis to treatment is often…
How HiFi sequencing lays the groundwork for accelerating rare disease diagnostics in the clinic
In February we are observing Rare Disease Month, a time to shine a light on the experiences of rare disease patients and their families. At PacBio, we are committed…
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Selected publications from January 2025
The start of 2025 is proving to be an influential moment for long-read sequencing, with a surge of research showcasing the power of PacBio HiFi sequencing. This month, we’re…
Sequencing 101: Epigenetics
Epigenetics is all about understanding how gene activity can change without altering the DNA sequence itself. Think of it as a “volume control” for your genes, turning them up…
Publication spotlight: Advancing plant breeding with long-read low-pass sequencing
We are energized from celebrating a Bright New Day at PAG last week! We had a fantastic time connecting with the plant and animal genomics community through collaborative discussions…
New Ampli-Fi ultra-low-input protocol will support HiFi sequencing from as little as 1 ng of DNA
Highly accurate long-read sequencing technologies have made it possible to generate genome assemblies at scale. In fact, HiFi sequencing is now the technology of choice for assembling reference-quality genomes…
PacBio 2024 Wrapped: A year of breakthroughs by the numbers
Onso short-read sequencing systems are no longer available through PacBio As we welcome a new year, we’re energized by what’s ahead—because of what we’ve accomplished together. 2024 was a…
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Selected publications from December 2024
As we close out 2024, the power of PacBio technology has never been more evident. December brought an inspiring array of research that highlights how HiFi sequencing is driving…
A father’s journey: finding hope through genomics
In Austin, Texas, Casey McPherson balances many roles—musician, entrepreneur, and most importantly, dad to his two daughters, Weston and Rose. But beneath the day-to-day rhythms of family life lies…
Garvan Institute researchers demonstrate that saliva samples are viable for long-read sequencing
Population studies, direct-to-consumer genetic tests, biobanks, and other large-scale genomic research projects rely on DNA gathered from saliva samples, which are often self-collected and submitted by the general public….
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Selected publications from November 2024
On the heels of ASHG, we are proud to see researchers leading the way with HiFi sequencing as the tool of choice to make groundbreaking discoveries. We are encouraged…
Lighting a SPRQ: How new Revio chemistry fuels innovative research
The genomics world is buzzing. A few weeks ago, PacBio introduced SPRQ chemistry for its Revio system, a leap forward for HiFi sequencing technology that’s igniting excitement among researchers…
Gaining deeper insight with targeted sequencing
Onso short-read sequencing systems are no longer available through PacBio Big things are happening at PacBio! The latest launches of the Vega system and SPRQ chemistry are creating quite…
Introducing the Vega system – HiFi sequencing within reach
The first benchtop HiFi long-read sequencing platform is now here with Vega, named after one of the brightest stars in the sky. This exciting platform builds out the…
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Selected publications from October 2024
PacBio HiFi sequencing technology continues to be the tool of choice for genomics professionals working at the forefront of discovery, enabling them to pursue new avenues of exploration across…