Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Data Release: Whole Human Transcriptome from Brain, Heart, and Liver
In higher eukaryotic organisms, like humans, RNA transcripts from the vast majority of genes are alternatively spliced. Alternative splicing dramatically increases the protein-coding potential of eukaryotic genomes and its regulation…
SMRT Sequencing for the HLA Complex: PacBio Goes to ASHI
This week marks the 40th annual meeting of the American Society for Histocompatibility and Immunogenetics, better known in the community as ASHI. The PacBio® team is looking forward to attending;…
New Chemistry Boosts Average Read Length to 10 kb – 15 kb for PacBio® RS II
We are pleased to announce the launch of our new reagent kit, P6-C4, which represents the next generation of our polymerase as well as our chemistry. This kit replaces the…
ASHG 2014: A New Look at the Human Genome with Long-Read Sequencing
Scientists around the world are getting ready for the annual meeting of the American Society of Human Genetics taking place October 18-22 at the San Diego Convention Center. We’re looking…
New Brain Study Reveals Higher Molecular Diversity from Alternative Splicing
A new paper from scientists in Switzerland and the US adds to recent findings about diversity of neuronal transcripts in the mammalian brain. The authors report that this study was…
‘The Quality of PacBio Data Is Beyond Compare’: Eric Schadt on Applications of SMRT Sequencing to Human Genetics
As part of its continuing series on long-read sequencing, last week Mendelspod aired an engaging interview with Eric Schadt, Professor & Chair of Genetics and Genomic Sciences, and Director of…
‘We’re Going to Find the Keys’: Dan Geraghty Discusses an Approach to Understanding Causal Genetic Variation
Dan Geraghty, a researcher at Fred Hutchinson Cancer Research Center and CEO of Scisco Genetics, has spent much of his career focused on the genetics of immune response. Recently he…
New Papers Detail Complexity of Methylome-Related Virulence in Human Pathogens
In two new publications, one published today, scientists from Australia, Italy, the UK, and the US report critical and surprising new findings about DNA methylation-related complexity of bacteria. Adding to…
Science Perspective: “Tracking Antibiotic Resistance”
In the current issue of Science there is an interesting Perspective by Scott Beatson and Mark Walker of the University of Queensland discussing research published this week in Science Translational…
Maryland Scientists Produce High-Quality, Cost-Effective Genome Assembly of Loa loa Roundworm Using SMRT Sequencing
A paper just released in BMC Genomics details what authors call “the most complete filarial nematode assembly published thus far at a fraction of the cost of previous efforts.” The…
NIH Study: Finished Genomes Provide Actionable Data to Combat Spread of Drug-Resistant Bacteria
A study launched over concerns around hospital-acquired infections has led to a recommendation for better microbial screening of patients upon admission. The research, from scientists at several NIH institutes, found…
The Rise of Long Reads: Mendelspod Podcast Series
Mendelspod host Theral Timpson kicked off a new podcast series this week on long-read sequencing that will include interviews with luminaries in the genomics field. Check out this introductory article…
Genome Analysis of Unicellular Organism Reveals Frequent, Massive Reshuffling
A recent publication from senior author Laura Landweber at Princeton University offers a remarkable and unexpected look at sweeping genomic rearrangements in a unicellular organism. “The Architecture of a Scrambled…
Genome-Wide Methylation in Human Microbiome Samples
Scientists in Florida and Finland recently published a report of their work studying methylation patterns in two human microbiome samples. While microbiome studies have become quite popular, the authors note…
Plant and Animal Genomes: New Web Resource Available
After so many compelling customer projects for microbial genomes, it’s been rewarding to see more scientists turning to Single Molecule, Real-Time (SMRT®) Sequencing for larger genomes, such as plants and…