Blog
December 16, 2014
At ASHI 2014, SMRT Sequencing Meets HLA Typing with Great Results
Earlier this fall, we headed to Denver for ASHI, or the annual meeting of the American Society for Histocompatibility and Immunogenetics. Though we’d attended this conference in the past, this…
December 11, 2014
Review Article: Long-Read Sequencing Offers Better Understanding of Pluripotency
A new review article offers a nice overview of attempts to characterize the transcriptome of human stem cells using RNA-seq, the Iso-Seq™ method, and more. Kin Fai Au and Vittorio…
December 4, 2014
A New Reference Genome for Shigella: SMRT Sequencing of a Historic Sample
In a special issue of The Lancet dedicated to World War I, an article by scientists from the Wellcome Trust Sanger Institute used Single Molecule, Real-Time (SMRT®) Sequencing to decode…
November 12, 2014
New Transcript Study Offers Clues to Pathogenesis of Repeat Disorders Linked to FMR1
It’s been nearly two years since a team of scientists from the University of California, Davis, School of Medicine published the first-ever complete sequence of FMR1, the gene associated with…
November 10, 2014
Nature Paper Offers Novel Sequence, Structural Variant Data for a More Complete Human Genome
A new paper out in Nature extends our view into the human genome and challenges current ideas about genetic variation. “Resolving the complexity of the human genome using single-molecule sequencing”…
October 29, 2014
‘Revolutionizing HLA Typing’: Uppsala’s Ulf Gyllensten on How Long Reads Give Access to New Areas of the Human Genome
In a recent interview with Theral Timpson — part of Mendelspod’s series on long-read sequencing — Ulf Gyllensten, a scientist at Uppsala University, spoke about using PacBio® technology for HLA…
October 21, 2014
Data Release: Whole Human Transcriptome from Brain, Heart, and Liver
In higher eukaryotic organisms, like humans, RNA transcripts from the vast majority of genes are alternatively spliced. Alternative splicing dramatically increases the protein-coding potential of eukaryotic genomes and its regulation…
October 20, 2014
SMRT Sequencing for the HLA Complex: PacBio Goes to ASHI
This week marks the 40th annual meeting of the American Society for Histocompatibility and Immunogenetics, better known in the community as ASHI. The PacBio® team is looking forward to attending;…
October 15, 2014
New Chemistry Boosts Average Read Length to 10 kb – 15 kb for PacBio® RS II
We are pleased to announce the launch of our new reagent kit, P6-C4, which represents the next generation of our polymerase as well as our chemistry. This kit replaces the…
October 10, 2014
ASHG 2014: A New Look at the Human Genome with Long-Read Sequencing
Scientists around the world are getting ready for the annual meeting of the American Society of Human Genetics taking place October 18-22 at the San Diego Convention Center. We’re looking…
October 9, 2014
New Brain Study Reveals Higher Molecular Diversity from Alternative Splicing
A new paper from scientists in Switzerland and the US adds to recent findings about diversity of neuronal transcripts in the mammalian brain. The authors report that this study was…
October 6, 2014
‘The Quality of PacBio Data Is Beyond Compare’: Eric Schadt on Applications of SMRT Sequencing to Human Genetics
As part of its continuing series on long-read sequencing, last week Mendelspod aired an engaging interview with Eric Schadt, Professor & Chair of Genetics and Genomic Sciences, and Director of…
October 2, 2014
‘We’re Going to Find the Keys’: Dan Geraghty Discusses an Approach to Understanding Causal Genetic Variation
Dan Geraghty, a researcher at Fred Hutchinson Cancer Research Center and CEO of Scisco Genetics, has spent much of his career focused on the genetics of immune response. Recently he…
September 30, 2014
New Papers Detail Complexity of Methylome-Related Virulence in Human Pathogens
In two new publications, one published today, scientists from Australia, Italy, the UK, and the US report critical and surprising new findings about DNA methylation-related complexity of bacteria. Adding to…
September 23, 2014
Science Perspective: “Tracking Antibiotic Resistance”
In the current issue of Science there is an interesting Perspective by Scott Beatson and Mark Walker of the University of Queensland discussing research published this week in Science Translational…