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This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.

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Welcome to Silicon Valley, Festival of Genomics!

This week the Festival of Genomics comes to the West Coast, and we’re excited to be a founding sponsor of the Front Line Genomics organization. Not only is it our…

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Scientists Sequence Klebsiella Strain Resistant to All Known Antibiotics

A new publication reports the discovery and analysis of a nightmare bacterium that’s genetically resistant to all commercially available classes of antibiotics. The paper, “Stepwise evolution of pandrug-resistance in Klebsiella pneumonia,”…

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Guest Blog: Rich Roberts Urges Scientists to ‘Think Methylation’ in Microbial Sequencing

Richard Roberts, Nobel Laureate and Chief Scientific Officer of New England Biolabs, offers his thoughts on the utility of methylation data for understanding prokaryotes. In his words: “Please run SMRT…

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Scientists Reveal Recent Autosome-to-Y Duplication Event in Drosophila

Following on the heels of characterizing 18 Mst77Y genes that were tandemly duplicated within a 96 kb region (Krsticevic FJ, et al., 2015), scientists from institutes in Brazil, Austria, and the…

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ASHG 2015: Highlights from the Platinum Genome Session and More

During the final days of the ASHG meeting last week in Baltimore, a number of scientists offered great presentations based on data generated with SMRT Sequencing, including an entire session…

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ASHG 2015: Highlights from Icahn Institute, UW, Stanford & CSHL Presentations

During the Wednesday afternoon sessions of last week’s ASHG conference, several speakers provided helpful insights about their use of SMRT Sequencing for a range of applications. Highlights included the following:…

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ASHG Workshop Recap & Recording: Addressing Hidden Heritability with SMRT Sequencing

The PacBio workshop at ASHG 2015 featured talks from two leaders in human genomics, Rick Wilson of Washington University and Richard Gibbs from Baylor University. Mike Hunkapiller, CEO of Pacific…

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ASHG 2015 Workshop Live Stream

Watch a recording of our AGBT 2015 workshop, “Addressing Hidden Heritability with Long-Read Single Molecule, Real-time (SMRT) Sequencing”:

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Beyond the $1,000 Genome: An Interview with Mark Gerstein

Next-generation sequencing has many people excited about the prospect of the $1,000 genome, however recent discoveries show that short-read sequencing technologies miss important genomic elements, driving scientists to look for…

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Toward Platinum Genomes: PacBio Releases a New, Higher-Quality CHM1 Assembly to NCBI

As part of our effort to support the National Institutes of Health and the Genome Reference Consortium (GRC) in creating platinum genomes for the research community and improving the reference…

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ASHG 2015: Workshop, Presentations, and First Chance to See the Sequel System

We’re looking forward to the year’s biggest scientific meeting focused on human genetics next week — the American Society of Human Genetics (ASHG) 2015 annual meeting, taking place in Baltimore,…

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Introducing the Sequel System: The Scalable Platform for SMRT Sequencing

We are excited to announce our newest Single Molecule, Real-Time sequencer, the Sequel™ System. Watch this short video to learn about this exciting evolution in SMRT® Sequencing. The Sequel System…

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Marc Salit at NIST: Defining Standards for the Human Genome

In the first podcast of a new series on the applications of long-read sequencing, Mendelspod host Theral Timpson interviewed Marc Salit, leader of the Genome Scale Measurements Group at the…

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At Genome in a Bottle Workshop, Progress on New Reference Materials

Genome in a Bottle consortium The National Institute of Standards and Technology held its latest Genome in a Bottle workshop last month in Gaithersburg, Md., and we were honored to…

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SMRTest Microbe Grant Winner: Identifying Antibiotic Resistance Mechanisms with SMRT Sequencing

We’re pleased to announce the winner of our recent “SMRTest Microbe” grant competition. Congratulations to Dr. Erin Price at the Menzies School of Health Research in Australia! The grant program,…

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