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This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.

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Powered by PacBio:
Selected publications from June 2025

What a month for Iso-Seq and Kinnex. The June 2025 edition of Powered by PacBio puts the spotlight on a suite of standout studies that tap into the full…

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Customer success story:
How Miami University is using long-read sequencing on the Vega system to train the next generation of scientists

At Miami University in Oxford, Ohio, genomics lives outside the lecture hall. It’s active, hands-on, and fully integrated into how students learn and how research gets done. At…

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How HiFi sequencing with the Ampli-Fi protocol can transform newborn screening with dried blood samples

Thanks to SPRQ chemistry and the Ampli-Fi protocol, researchers are now unlocking whole genomes from one of the most notoriously tricky sample types: dried blood spots (DBS). Collected from…

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Celebrating Father’s Day with new discoveries of the Y chromosome achieved with HiFi sequencing

With Father’s Day around the corner, we’re raising a glass in honor of the dads, granddads, and father figures who show up with heart, humor, and a helping hand….

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Powered by PacBio:
Selected publications from May 2025

This month’s May 2025 publication roundup showcases how researchers are using PacBio HiFi sequencing to generate deeper insight into persistent scientific challenges. From uncovering hidden HIV-1 reservoirs, to revealing…

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A roadmap to expand PureTarget repeat expansion and carrier panels, enabling high-throughput clinical research solutions

We just wrapped up the European Society of Human Genetics (ESHG) Conference in Milan Italy, surrounded by researchers, collaborators, and a shared focus on the future of human genomics….

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HiFi sequencing uncovers the secret to aging gracefully in Earth’s oldest living organisms

If you’re looking for good advice on how to live a long and healthy life, you might ask someone who’s been around the block a few times. Or, in…

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Cancer research gains a powerful new tool as Ampli-Fi makes HiFi sequencing possible for FFPE-preserved samples

Cancer research depends on the details we can actually see. And, until now, FFPE samples have not been compatible with long-read sequencing. That’s changing. This year at AACR, we…

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Powered by PacBio:
Selected publications from April 2025

This month’s April 2025 roundup features new research using PacBio HiFi sequencing to investigate unresolved questions in human health, evolution, and agriculture. From rethinking the genetic cause of a…

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Customer success story:
How Berry Genomics is transforming complex single-gene disorder assays with HiFi sequencing

As one of China’s most prominent clinical genomics companies, Berry Genomics has a sharp focus on the prevention of genetic birth defects. Their team is constantly on the search…

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Celebrating DNA Day and the long-read sequencing tools moving genomics forward

At PacBio, we’re celebrating DNA Day with excitement and appreciation—not just for what DNA is, but for how far we’ve come in decoding it. Each year on April 25,…

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Customer success story:
How SPRQ chemistry boosts data output across continents at Signios Biosciences

What happens when one of the world’s top genomics service providers gets their hands on cutting-edge chemistry? Big things. At Signios Biosciences, innovation is the engine that drives powerful…

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DNA extraction tips and best practices for HiFi sequencing

DNA extraction is the first step of any sequencing project. It’s often considered the easiest part of the workflow, compared to the more complicated steps of library prep, sequencing,…

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Customer success story: The University of Bern takes long-read sequencing to the next level with SPRQ chemistry

The new SPRQ chemistry for the Revio system is making high-quality long-read sequencing more efficient than ever—delivering more data from less input without compromising accuracy or cost efficiency. But…

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Powered by PacBio:
Selected publications from March 2025

This month’s publications show how PacBio HiFi sequencing is being used to address complex problems in clinical genetics, brain research, and crop development. The March 2025 edition of our…

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