Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Study Used Iso-Seq Method to Unravel Activity of Receptors in Prostate Cancer
A new publication in Clinical Cancer Research from scientists at the Mayo Clinic, University of Minnesota, and other institutions presents results from a study to evaluate androgen receptor (AR) isoforms…
Iso-Seq Data Supports Annotation Efforts for Key Crops Wheat and Barley
Two recent papers underscore the importance of using PacBio full-length RNA sequencing to interrogate transcriptomes for major crops. Together, these publications offer compelling evidence that information considered essential for crop…
Stanford Scientists Report First Use of PacBio Whole Genome Sequencing to Identify a Disease-Causing Mutation
An article published today in Genetics in Medicine from Jason Merker, Euan Ashley, and colleagues at Stanford University reports the first successful application of PacBio whole genome sequencing to identify a…
At SMRT Leiden, Improvements in Characterizing Genomes, Transcriptomes, and Methylomes
Last month, we co-hosted the 2nd annual SMRT Leiden conference with Leiden University Medical Center. SMRT Leiden featured three days of excellent presentations, including one day focused on bioinformatics. If…
New Maize Reference Genome Will Support Crop Improvement Programs
A large group of scientists published a new reference genome assembly for maize. It was generated with SMRT Sequencing and other technologies, and represents a major leap forward in accurately…
Scientists Use SMRT Sequencing to Reveal Unexpected Adhesin Repertoire in Candida
In a preprint available from bioRxiv, scientists from the University of Lausanne and Swiss Institute of Bioinformatics present the first SMRT Sequencing results from isolates of the fungal pathogen Candida…
Widespread Methylation in Earliest Fungi Offers Clue to Expression of Essential Genes
The Joint Genome Institute recently announced results from a project that used SMRT Sequencing to generate high-quality genome assemblies and detect epigenetic modifications for fungal species that represent the earliest…
At CROPS 2017, SMRT Sequencing Powers Reference Plant Genome Assemblies
This week the HudsonAlpha Institute for Biotechnology and the University of Georgia are co-hosting CROPS 2017, a meeting focused on genomic technologies and their use in crop improvement and breeding…
In Texas, New View of Klebsiella Strain Diversity and Antibiotic Resistance
A sweeping new report on Klebsiella pneumoniae sequence data from scientists at the Houston Methodist Research Institute, Weill Cornell Medical College, and other institutions found more diversity than expected in strains…
At ASM Microbe 2017, SMRT Sequencing Advances Microbial Applications
We can’t wait for ASM Microbe! It’s one of the largest microbiology conferences in the world and is taking place June 1-5 in New Orleans. With more than 10,000 people…
Genome Assembly Advances Featured in Genome Research Special Issue
The May issue of Genome Research is a special edition focusing on advances in sequencing technologies and genome assembly techniques. The research papers selected for this special issue cover reference-grade…
TB Study Finds Some Previously Reported Virulence Variants Were Sequencing Errors
A publication in BMC Genomics upends some of the conventional wisdom about variants that may cause virulence in Mycobacterium tuberculosis. Scientists at San Diego State University used SMRT Sequencing to…
New Iso-Seq Chicken Analysis Finds Missing Genes and Transcript Complexity
A new publication in BMC Genomics explores the use of RNA normalization and 5’ cap selection to enhance results from Iso-Seq studies using SMRT Sequencing. Scientists from the University of…
SMRT Sequencing Enables Accurate Calling of Pathogenic Variants in Medically Relevant Genes
Screening for pathogenic variants associated with polycystic kidney disease is now more accurate and affordable with SMRT Sequencing. A new paper in Human Mutation from scientists at Leiden University Medical…
Happy DNA Day! A Celebration of Great Science
It’s DNA Day, the annual celebration of the discovery of the double helix, the completion of the Human Genome Project, and all things genetic. We like to take the opportunity…