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This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.

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How HiFi sequencing achieves scalable microbial genomics without compromise

Microbes touch every part of our lives. They’re what make up the beneficial communities living in our guts and the pathogens that drive major public health crises. If you’re…

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Selected publications from September 2025

This month’s publications show just how versatile HiFi sequencing has become. In September, studies ranged from building the most comprehensive map yet of human genomic imprinting, to evaluating clinical…

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How PureTarget is modernizing research into carrier screening

As many as 7 in 10 people carry at least one pathogenic genetic variant, even if they have no family history of disease1. That means most couples could unknowingly…

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The growing importance of carrier screening in genomics

Carrier screening is one of the most influential ways genetics is shaping the future of human health. By revealing inherited risks before they ever appear, carrier screening has changed…

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2025 Microbiome SMRT Grant Awardees

We are thrilled to announce the winners of the 2025 Microbiome SMRT Grant for HiFi shotgun metagenomics. This year’s program received hundreds of amazing proposals from researchers around the…

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Selected publications from August 2025

This month’s publication highlights show how HiFi sequencing is helping researchers tackle challenges across clinical genomics research. See how HiFi is helping researchers sequence ultra-low input cancer samples, profile…

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Looking to make sense of your research? There’s HiFi for that

The coffee’s cold, your pipette tips are backordered, and someone just booked your favorite lab bench. Science can be full of small annoyances. We can’t solve them all, but…

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Fast-track biopharma breakthroughs with HiFi long-read sequencing

In biopharmaceutical research and development, the path from discovery to approved therapy can be long and complex, requiring innovation at every step. Success depends on understanding biology at its…

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Sequencing 101: How multiplexing with long-read sequencing makes genomic research faster, cheaper, and smarter

Sequencing is the backbone of modern genomics. It has evolved over time, and as platforms grow to be faster and more accurate, researchers are finding new ways to maximize…

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Selected publications from July 2025

In July 2025’s publication roundup we’re proud to show how HiFi sequencing is playing a major role in advancing our understanding of the human brain, and autism in particular….

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Customer success story:
How Dr. Ibrahim Bitar is doubling his research impact while leading the future of European genomics from the Czech Republic

When it comes to microbial genomics, Dr. Ibrahim Bitar doesn’t back down from a challenge. As an Assistant Professor of Microbiology at Charles University in Prague, and CEO of…

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Publication spotlight: How Kinnex long-read RNA sequencing wins out over Illumina for transcript-level quantification

Kinnex has been making a splash since the day it launched – showing up in talks, turning heads in RNA labs, and putting its use cases solidly in the…

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How long-read sequencing uncovers hitchhikers of the genomic galaxy in parasitic fungi

In the sci-fi classic The Hitchhiker’s Guide to the Galaxy, interstellar explorers hitch rides aboard ships that take them on wild, unexpected journeys across the cosmos. In a new…

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Sequencing 101: Software and bioinformatics powering long-read sequencing

Today’s genome sequencing is nothing short of transformative. But the technology’s true potential isn’t unlocked by chemistry alone, it’s the software that brings it to life. If sequencing is…

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Selected publications from June 2025

What a month for Iso-Seq and Kinnex. The June 2025 edition of Powered by PacBio puts the spotlight on a suite of standout studies that tap into the full…

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