Blog
August 30, 2023
Iso-Seq method outperforms other long-read methods in benchmarking consortium study
A benchmarking of long-read RNA sequencing methods and analysis tools The Long-read RNA-Seq Genome Annotation Assessment Project (LRGASP) consortium, an initiative to systematically evaluate methods for transcript identification and quantification,…
August 23, 2023
Why SBB could be a game-changer for liquid biopsy research
Onso short-read sequencing systems are no longer available through PacBio PacBio HiFi long-read sequencing technology has made huge strides in helping us understand tumor biology, from the ability to call…
August 15, 2023
Faster and more affordable sequencing with the HiFi microbial high-throughput workflow
Highly-accurate HiFi reads produced by PacBio long-read sequencers –such as the Sequel IIe and Revio systems– enable researchers to access entirely new levels of contiguity, completeness, and accuracy when assembling…
August 8, 2023
Sequencing 101: SBB sequencing
Onso short-read sequencing systems are no longer available through PacBio Since the inception of next generation sequencing (NGS) more than a decade ago, short-read sequencing accuracy has seen only marginal…
August 1, 2023
Watch: A method for chromosome-level phasing of HiFi assemblies
As more researchers embrace the benefits of PacBio long-read sequencing technology, an expanding community of analysis tool developers has taken shape. Thanks to this growing excitement around PacBio capabilities there…
July 28, 2023
A HiFi movement: Isoform-resolved cell atlases
Cellular cartography has been just as important for biologists to navigate the complex topography of living systems as was the mapping of the earth’s landscapes for explorers hundreds of years…
July 18, 2023
Beyond borders: The 2023 Discoveries Roadshow ignites curiosity worldwide
Onso short-read sequencing systems are no longer available through PacBio Scientific breakthroughs are rarely achieved in isolation. They require collaboration, cutting-edge techniques, and a platform where scientists can come together…
July 14, 2023
The next era of plant + animal genomics has begun
The new Revio long-read sequencing system, with its first customer shipment in March 2023, has changed the game in genomics. It enables researchers to access an entirely new echelon of…
July 6, 2023
Sequencing 101: The SMRT Cell in PacBio long-read sequencing
Last updated: 24 April 2026 If you have ever clicked around the PacBio website, or attended a workshop or webinar discussing PacBio long-read sequencing technology, then you have probably seen…
June 29, 2023
Population genomics isn’t ‘one-size-fits-all’
Delve deeper into the importance of capturing diversity with population-specific reference pangenomes. The movement towards the development of pangenomes is gaining steam, bringing the reality of truly personalized medicine closer….
June 27, 2023
Sequencing with the Revio system is as easy as it is powerful
The Revio system was built with the belief that game-changing technology should be simple to use. For a technology to be truly revolutionary it should deliver superior performance in conjunction…
June 14, 2023
A HiFi movement – reference pangenomes
Fresh off the special Nature issue last month on the first human pangenome reference (featured in a previous blog), the first regional human pangenome reference study, entitled A Pangenome Reference…
June 7, 2023
Cracking cancer: Using long-read RNA sequencing for cancer neoantigen discovery
When developing effective personalized immunotherapies, such as cancer vaccines, a pivotal factor lies in uncovering tumor neoantigens that can serve as crucial therapeutic targets. Traditionally, neoantigen discovery heavily relied on…
May 24, 2023
Beyond short reads: Harnessing long-read sequencing for population-scale genomic insights
Large-scale population sequencing programs have a number of important research goals and outcomes. These include: Generating a comprehensive catalogue of genetic variation to reflect the genetic diversity in a target…
May 18, 2023
Sequencing 101: Sequencing coverage
This article explores sequencing coverage fundamentals. Uncover key concepts and discover how highly accurate long-read sequencing provides a comprehensive view of the genome, at any coverage level. What is sequencing…