Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
SMRT Sequencing of Chicken Heart Transcripts Yields New Genes and Isoforms
The Gallus gallus (common chicken) genome was initially published in 2004, but the latest RefSeq and Ensembl annotations remain incomplete. The chicken is an important model organism, especially for research…
Innovation Centre in Quebec Uses SMRT Sequencing for
Cost-Effective, Complete Microbial Genomes
At the McGill University and Génome Québec Innovation Centre, many projects conducted in the sequencing core facility fall under the umbrella of life sciences rather than biomedical research. To the…
Webinar Recap: Automating PacBio 10 kb template preparation
During our recent sample prep webinar, PacBio® scientists described new automated options for the 10 kb SMRTbell™ template preparation workflow. In case you didn’t have the chance to attend, here’s…
GC-Rich Genome of Pandoraea Bacterium Assembled with SMRT Sequencing
Scientists from the Institute of Biological Sciences at the University of Malaya recently published a description of Pandoraea sp. strain RB-44 in Genome Announcements, a journal from the American Society…
FDA-Supported Pathogen Database to Expand with SMRT Sequencing
We’re delighted to report that Single Molecule, Real-Time (SMRT®) Sequencing will be a crucial technology in a new research program conducted by the University of Maryland School of Medicine. The…
Deep Thoughts by Ken Dewar from McGill University
Scientist Ken Dewar from McGill University discusses his vast expertise in next-generation sequencing, some little-known facts about the launch of the 454 platform, and a revolutionary business idea for researchers…
New Software Release: SMRT Analysis Upgrade for Iso-Seq Analysis and HLA Allele Phasing
Today we announced the release of a software upgrade for our Single Molecule, Real-Time (SMRT®) DNA Sequencing platform. SMRT Analysis 2.2 provides enhanced functionality to support two additional applications that…
This Week: Sample Prep Webinar on 10 Kb Template Prep
If you love long reads, you won’t want to miss this week’s webinar on sample prep for Single Molecule, Real-Time (SMRT®) Sequencing. We will focus on automation solutions for 10…
As Genome Editing Gains Traction, SMRT Sequencing Provides Accurate View of Results
A new paper published in Cell Reports describes how Single Molecule, Real-Time (SMRT®) Sequencing can be used to greatly improve outcome reporting for a variety of popular genome-editing approaches. “Quantifying…
Importance of Finished Microbial Genome Highlighted for Ethanol-Generating Clostridium
A paper in BioMed Central’s Biotechnology for Biofuels journal demonstrates how finished microbial genomes using Single Molecule, Real-Time (SMRT®) Sequencing are having an impact on the biotechnology industry. The publication,…
ABRF Preview: Off to the Land of Core Labs and Hot Air Balloons
Members of the PacBio team will be heading down to Albuquerque this weekend for the annual conference of the Association of Biomolecular Resource Facilities (ABRF). It’s a big year for…
Assessment of Highly Complex Alternative Splicing of Neurexins Performed with SMRT Sequencing
A new paper in the Proceedings of the National Academy of Sciences from the laboratories of Stephen R. Quake and Thomas C. Südhof (both at Stanford University) describes the direct,…
AGBT 2014 Presentation Videos: SMRT Sequencing at CSHL, Uppsala U., and Baylor College of Medicine
There were several excellent talks showcasing SMRT® Sequencing data at the annual Advances in Genome Biology and Technology conference. If you didn’t have the opportunity to see them in person,…
In Acinetobacter Study, Long Reads Aid in Defining Genomic Structure
A paper recently published in mBio, an open access journal from the American Society for Microbiology, reports on the sequencing and phylogenetic analysis of several drug-resistant strains of a pathogen…
AGBT Day 3 Highlights: Single Contigs, Dazzling Assemblers, Novel Isoforms & Honey Algorithms
Friday morning’s talks were exceptional, and included genomics heavy-hitters Dick McCombie and Gene Myers — both scientists who were truly influential in sequencing the human genome so many years ago….