HiFi sequencing can take your research to the next level, from discovery across the drug development process
Many applications in the drug discovery and development process benefit from highly accurate long reads. With the Vega benchtop long-read system, users can apply these highly accurate long reads to applications like AAV genome characterization, on- and off-target gene editing assessment, scFv antibody development, mRNA vaccine critical quality attribute measurement, insertion site analysis, plasmid sequencing, and cell line characterization.
Gene therapy
Discover, verify, and improve AAV vector design with full-length, highly accurate AAV.
Gene editing
Assess on- and off-target CRISPR-Cas9 gene editing outcomes and conduct insertion site analysis.
Biologics R&D
Enhance your work on biologics, from plasmid sequencing, cell line verification, mRNA full length sequencing, to directed evolution.
Application brief
Vega benchtop HiFi sequencing for biopharma research
On the Vega system, you have access to affordable HiFi long-read sequencing with streamlined end-to-end workflows from sample prep to analysis. New SPRQ-Nx chemistry now enables you to get more sequencing output from less input material. Additionally, support for 21 CFR Part 11 compliance is now enabled on Vega, so you can seamlessly move assays from research to regulated environments like GMP.
Target and biomarker identification
Comprehensively analyze your samples to identify and validate novel targets and biomarkers
- Capture SNPs, indels, and larger structural variants to identify novel targets or biomarkers
- Identify novel RNA isoforms, fusion transcripts and gene expression patterns
- Integrate epigenetic information into your results with DNA methylation and chromatin accessibility data
- Generate more comprehensive multiomic datasets
Cell and gene therapy
Design and evaluate the most promising cell and gene therapies for the next generation of novel disease treatments
- Discover, design, and evaluate novel AAV vectors
- Comprehensively analyze virus and construct integration sites
- Confirm plasmid and cell line identity and integrity
- Fully characterize CRISPR-Cas9 gene editing outcomes
Biologics development
Highly accurate sequencing can elevate some of the most commonly used approaches in biologics research and development
- Confirm complete plasmid sequences including its backbone
- Characterize mRNA vaccines including polyA-tail length
- Develop novel proteins with desired characteristics
- Confirm cell line identity and genomic integrity
