The emergence and intercontinental spread of a multidrug-resistant clade of typhoid agent Salmonella enterica serovar Typhi

Authors: Wong, Vanessa K and Baker, Stephen and Pickard, Derek and Page, Andrew J and Feasey, Nicholas A and Dougan, Gordon and Holt, Kathryn E

Multidrug-resistant typhoid is a global health problem. Previous studies conducted in countries of Asia and Africa have identified a highly clonal, multidrug-resistant lineage of Salmonella enterica serovar Typhi (S Typhi), known as H58. However, little is known about the emergence and geographical spread of the H58 clade. In this study, we have used whole-genome sequencing of a global collection of S Typhi to investigate this highly successful lineage.

Journal: The Lancet
DOI: 10.1016/S0140-6736(16)00397-4
Year: 2016

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