July 7, 2019  |  

Salmonella degrades the host glycocalyx leading to altered infection and glycan remodeling.

Authors: Arabyan, Narine and Park, Dayoung and Foutouhi, Soraya and Weis, Allison M and Huang, Bihua C and Williams, Cynthia C and Desai, Prerak and Shah, Jigna and Jeannotte, Richard and Kong, Nguyet and Lebrilla, Carlito B and Weimer, Bart C

Complex glycans cover the gut epithelial surface to protect the cell from the environment. Invasive pathogens must breach the glycan layer before initiating infection. While glycan degradation is crucial for infection, this process is inadequately understood. Salmonella contains 47 glycosyl hydrolases (GHs) that may degrade the glycan. We hypothesized that keystone genes from the entire GH complement of Salmonella are required to degrade glycans to change infection. This study determined that GHs recognize the terminal monosaccharides (N-acetylneuraminic acid (Neu5Ac), galactose, mannose, and fucose) and significantly (p?

Journal: Scientific reports
DOI: 10.1038/srep29525
Year: 2016

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