Prognostic significance of novel katG mutations in Mycobacterium tuberculosis

Authors: Valafar, F and Ramirez-Busby, SM and Torres, J and Paul, Lynthia V and Rodwell, TC and Victor, TC and Rodrigues, C and Gler, MT and Crudu, V and Catanzaro, T

By using whole genome sequencing (WGS), researchers are beginning to understand the genetic diversity of Mycobacterium tuberculosis (MTB) and its consequences for the diagnosis of multidrug-resistant tuberculosis (MDR–TB) on a genomic scale. The Global Consortium for Drug-resistant TB Diagnostics (GCDD) conducted a genome scale variant analyses of 366 clinical MTB genomes (mostly MDR/XDR [extensively drug resistant]) from four countries in order to inform the development of rapid molecular diagnostics. This project has been extended by performing an evolutionary analysis of isoniazid (INH)-resistant isolates for prognostic purposes.

Journal: International journal of mycobacteriology
DOI: 10.1016/j.ijmyco.2014.11.043
Year: 2015

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