Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.

Authors: Wright, Meredith S and Perez, Federico and Brinkac, Lauren and Jacobs, Michael R and Kaye, Keith and Cober, Eric and van Duin, David and Marshall, Steven H and Hujer, Andrea M and Rudin, Susan D and Hujer, Kristine M and Bonomo, Robert A and Adams, Mark D

Genome sequencing of carbapenem-resistant Klebsiella pneumoniae isolates from regional U.S. hospitals was used to characterize strain diversity and the bla(KPC) genetic context. A phylogeny based on core single-nucleotide variants (SNVs) supports a division of sequence type 258 (ST258) into two distinct groups. The primary differences between the groups are in the capsular polysaccharide locus (cps) and their plasmid contents. A strict association between clade and KPC variant was found. The bla(KPC) gene was found on variants of two plasmid backbones. This study indicates that highly similar K. pneumoniae subpopulations coexist within the same hospitals over time. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Journal: Antimicrobial agents and chemotherapy
DOI: 10.1128/AAC.00125-14
Year: 2014

Read publication