July 7, 2019  |  

Plasmid-mediated colistin resistance in a patient infected with Klebsiella pneumoniae.

Authors: Nicolet, Stefan and Goldenberger, Daniel and Schwede, Torsten and Page, Malcolm and Creus, Marc

It is alarming that the plasmid-mediated mcr-1-encoded colistin resistance discovered by Yi-Yun Liu and colleagues,1 probably selected in cows and pigs as discussed by Marisa Haenni and colleagues2 and Surbhi Malhorta-Kumar and colleagues,3 is now spreading globally in Gram-negative pathogens.4 Moreover, colistin-resistant Escherichia coli without the canonical mcr-1 gene suggest that other (transferable) colistin-resistant mechanisms exist.3

Journal: The Lancet. Infectious diseases
DOI: 10.1016/S1473-3099(16)30197-9
Year: 2016

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