MCR-1 and OXA-48 in vivo acquisition in KPC-producing Escherichia coli after colistin treatment.

Authors: Beyrouthy, Racha and Robin, Frederic and Lessene, Aude and Lacombat, Igor and Dortet, Laurent and Naas, Thierry and Ponties, Valérie and Bonnet, Richard

The spread of mcr-1-encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France. Copyright © 2017 American Society for Microbiology.

Journal: Antimicrobial agents and chemotherapy
DOI: 10.1128/AAC.02540-16
Year: 2017

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