July 7, 2019  |  

Linear peptides are the major products of a biosynthetic pathway that encodes for cyclic depsipeptides.

Authors: Wyche, Thomas P and Ruzzini, Antonio C and Beemelmanns, Christine and Kim, Ki Hyun and Klassen, Jonathan L and Cao, Shugeng and Poulsen, Michael and Bugni, Tim S and Currie, Cameron R and Clardy, Jon

Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The structures of the complex nonribosomal peptide synthetase-polyketide synthase (NRPS/PKS) hybrid compounds were determined by 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Both cyclic and linear peptides are reported, and the genetic organization of the NRPS modules within the biosynthetic gene cluster accounts for the observed structural diversity.

Journal: Organic letters
DOI: 10.1021/acs.orglett.7b00545
Year: 2017

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