July 7, 2019  |  

Identification of the polyketide biosynthetic machinery for the indolizidine alkaloid cyclizidine.

Authors: Huang, Wei and Kim, Seong Jong and Liu, Joyce and Zhang, Wenjun

The cyclizidine biosynthetic gene cluster was identified from Streptomyces NCIB 11649, which revealed the polyketide biosynthetic machinery for cyclizidine alkaloid biosynthesis. Both in vivo mutagenesis study and in vitro biochemical analysis provided insight into the timing and mechanism of the biosynthetic enzymes that produce cyclizidine-type indolizidine alkaloids.

Journal: Organic letters
DOI: 10.1021/acs.orglett.5b02707
Year: 2015

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