July 7, 2019  |  

Genomic insights into the virulence and salt tolerance of Staphylococcus equorum.

Authors: Jeong, Do-Won and Heo, Sojeong and Ryu, Sangryeol and Blom, Jochen and Lee, Jong-Hoon

To shed light on the genetic background behind the virulence and salt tolerance of Staphylococcus equorum, we performed comparative genome analysis of six S. equorum strains. Data on four previously published genome sequences were obtained from the NCBI database, while those on strain KM1031 displaying resistance to multiple antibiotics and strain C2014 causing haemolysis were determined in this study. Examination of the pan-genome of five of the six S. equorum strains showed that the conserved core genome retained the genes for general physiological processes and survival of the species. In this comparative genomic analysis, the factors that distinguish the strains from each other, including acquired genomic factors in mobile elements, were identified. Additionally, the high salt tolerance of strains enabling growth at a NaCl concentration of 25% (w/v) was attributed to the genes encoding potassium voltage-gated channels. Among the six strains, KS1039 does not possess any of the functional virulence determinants expressed in the other strains.

Journal: Scientific reports
DOI: 10.1038/s41598-017-05918-5
Year: 2017

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