Genome analysis of Kingella kingae strain KWG1 reveals how a ß-Lactamase gene inserted in the chromosome of this species.

Authors: Bidet, Philippe and Basmaci, Romain and Guglielmini, Julien and Doit, Catherine and Jost, Christelle and Birgy, André and Bonacorsi, Stéphane

We describe the genome of a penicillinase-producing Kingella kingae strain (KWG1), the first to be isolated in continental Europe, whose blaTEM-1 gene was, for the first time in this species, found to be chromosomally inserted. The blaTEM gene is located in an integrative and conjugative element (ICE) inserted in Met-tRNA and comprising genes that encode resistance to sulfonamides, streptomycin, and tetracycline. This ICE is homologous to resistance-conferring plasmids of K. kingae and other Gram-negative bacteria. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Journal: Antimicrobial agents and chemotherapy
DOI: 10.1128/AAC.02192-15
Year: 2015

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