Genetic Analysis of p17S-208 Plasmid Encoding the Colistin Resistance mcr-3 Gene in Escherichia coli Isolated from Swine in South Korea.

Authors: Belaynehe, Kuastros Mekonnen and Shin, Seung Won and Park, Kyung Yoon and Jang, Ji Young and Won, Ho Geun and Yoon, In Joong and Yoo, Han Sang

We screened, for the first time, plasmid-mediated colistin resistance mcr-3 genes among 636 Escherichia coli isolates collected from swine in South Korea. Whole-genome sequencing showed that the E. coli strain harbored the mcr-3 gene in a p17S-208 plasmid with an IncHI2-ST3 plasmid type and a size of 260,399 base pairs. The deduced amino acid sequences revealed that persistent evolution in the bacterial genome has resulted in mcr gene variants. There is a need for extensive surveillance to prevent the dissemination of colistin resistance mcr genes from animal to human.

Journal: Microbial drug resistance
DOI: 10.1089/mdr.2018.0132
Year: 2019

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