July 7, 2019  |  

First report of blaOXA-499 as a carbapenemase gene from Acinetobacter pittii.

Authors: D'Souza, Roshan and Pinto, Naina and Higgins, Paul G and Hwang, Insik and Yong, Dongeun and Choi, Jongrak and Lee, Kyoungwon and Chong, Yunsop

We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143 from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143 and the gene was located on the chromosome. By cloning the OXA-499 encoding gene into the pWH1266 vector and transforming into susceptible Acinetobacter spp, we were able to show that OXA-499 confers resistance to carbapenems. Copyright © 2017 American Society for Microbiology.

Journal: Antimicrobial agents and chemotherapy
DOI: 10.1128/AAC.02676-16
Year: 2017

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