July 7, 2019  |  

First report of blaIMP-14 on a plasmid harboring multiple drug resistance genes in Escherichia coli ST131.

Authors: Stoesser, Nicole and Sheppard, Anna E and Peirano, Gisele and Sebra, Robert and Lynch, Tarah and Anson, Luke and Kasarskis, Andrew and Motyl, Mary R and Crook, Derrick W and Pitout, Johann D

The blaIMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant E. coli, we identified an ST131 strain harboring blaIMP-14 within a class 1 integron, itself nested within a ~54kb multi-drug resistance region on an epidemic IncA/C2 plasmid. The emergence of blaIMP-14 in this context in the ST131 lineage is of potential clinical concern. Copyright © 2016 Stoesser et al.

Journal: Antimicrobial agents and chemotherapy
DOI: 10.1128/AAC.00840-16
Year: 2016

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