Emergence of ileS2-carrying, multidrug-resistant plasmids in Staphylococcus lugdunensis.

Authors: Ho, Pak-Leung and Liu, Melissa Chun-Jiao and Chow, Kin-Hung and Tse, Cindy Wing-Sze and Lo, Wai-U and Mak, Siu-Ka and Lo, Wai-Kei

Of 137 Staphylococcus lugdunensis isolates collected from two nephrology centers in Hong Kong, 10 (7.3%) and 3 (2.2%) isolates had high-level and low-level mupirocin resistance, respectively. Isolates with high-level resistance contained the plasmid-mediated ileS2 gene, while isolates with low-level resistance contained the mutation V588F within the chromosomal ileS gene. All but one of the ileS2-positive isolates belong to the predominating clone HKU1. Plasmids carrying the ileS2 gene were mosaic and also cocarry multiple other resistance determinants. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Journal: Antimicrobial agents and chemotherapy
DOI: 10.1128/AAC.00948-16
Year: 2016

Read publication