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Authors: Chen, Zelin and Omori, Yoshihiro and Koren, Sergey and Shirokiya, Takuya and Kuroda, Takuo and Miyamoto, Atsushi and Wada, Hironori and Fujiyama, Asao and Toyoda, Atsushi and Zhang, Suiyuan and Wolfsberg, Tyra G and Kawakami, Koichi and Phillippy, Adam M and Mullikin, James C and Burgess, Shawn M

For over a thousand years, the common goldfish (Carassius auratus) was raised throughout Asia for food and as an ornamental pet. As a very close relative of the common carp (Cyprinus carpio), goldfish share the recent genome duplication that occurred approximately 14 million years ago in their common ancestor. The combination of centuries of breeding and a wide array of interesting body morphologies provides an exciting opportunity to link genotype to phenotype and to understand the dynamics of genome evolution and speciation. We generated a high-quality draft sequence and gene annotations of a "Wakin" goldfish using 71X PacBio long reads. The two subgenomes in goldfish retained extensive synteny and collinearity between goldfish and zebrafish. However, genes were lost quickly after the carp whole-genome duplication, and the expression of 30% of the retained duplicated gene diverged substantially across seven tissues sampled. Loss of sequence identity and/or exons determined the divergence of the expression levels across all tissues, while loss of conserved noncoding elements determined expression variance between different tissues. This assembly provides an important resource for comparative genomics and understanding the causes of goldfish variants.

Journal: Science advances
DOI: 10.1126/sciadv.aav0547
Year: 2019

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