July 7, 2019  |  

Conjugative ESBL plasmids differ in their potential to rescue susceptible bacteria via horizontal gene transfer in lethal antibiotic concentrations.

Authors: Mattila, Sari and Ruotsalainen, Pilvi and Ojala, Ville and Tuononen, Timo and Hiltunen, Teppo and Jalasvuori, Matti

Emergence (and proliferation) of resistant pathogens under strong antibiotic selection is an evolutionary process where bacteria overcome the otherwise growth inhibiting or lethal concentration of antimicrobial substances. In this study, we set to investigate a largely unexplored mechanism, namely evolutionary rescue (that is, adaptive evolutionary change that restores positive growth to declining population and prevents extinction) via horizontal gene transfer, by which new resistant bacteria may emerge both in and out of clinical environments.

Journal: The Journal of antibiotics
DOI: 10.1038/ja.2017.41
Year: 2017

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