Complete genome sequence of the Gram-negative probiotic Escherichia coli strain Nissle 1917.

Authors: Reister, Marten and Hoffmeier, Klaus and Krezdorn, Nicolas and Rotter, Bjoern and Liang, Chunguang and Rund, Stefan and Dandekar, Thomas and Sonnenborn, Ulrich and Oelschlaeger, Tobias A

Escherichia coli strain Nissle 1917 (EcN) is the active principle of a probiotic preparation (trade name Mutaflor(®)) used for the treatment of patients with intestinal diseases such as ulcerative colitis and diarrhea. It has GRAS (generally recognized as save) status and has been shown to be a therapeutically effective drug (Sonnenborn and Schulze, 2009). The complete genomic DNA sequence will help in identifying genes and their products which are essential for the strains probiotic nature. Genbank/EMBL/DDBJ accession number: CP007799 (chromosome). Copyright © 2014 Elsevier B.V. All rights reserved.

Journal: Journal of biotechnology
DOI: 10.1016/j.jbiotec.2014.07.442
Year: 2014

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