Complete genome sequence of Achromobacter spanius type strain DSM 23806T, a pathogen isolated from human blood.

Authors: Li, Gengmi and Yang, Li and Zhang, Tao and Guo, Xiaojiao and Qin, Jian and Cao, Yingjiang and Yang, Qianhua and You, Shumei and Yuan, Guoliang and Wan, Xianqi and Luo, Jing and Li, Zhaoxiang and Gao, Lei and Liu, Ying and Jiang, Kaifeng and Zheng, Jiakui

Achromobacter spanius is a newly described, non-fermenting, Gram-negative, coccoid pathogen isolated from human blood. Whole-genome sequencing of the A. spanius type strain was performed to investigate the mechanism of pathogenesis of this strain at a genomic level.The complete genome of A. spanius type strain DSM 23806T was sequenced using single-molecule real-time (SMRT) DNA sequencing.The complete genome of DSM 23806T consists of one circular DNA chromosome of 6425783bp with a G+C content of 64.26%. The entire genome contains 5804 predicted coding sequences (CDS) and 55 tRNAs. Genomic island (GI) analysis showed that this strain encodes several important pathogenesis- and resistance-related genes.These results strongly suggest that GIs provide some fitness advantages in A. spanius type strain DSM 23806T. This report provides an extensive understanding of A. spanius at a genomic level as well as an understanding of the evolution of A. spanius. Copyright © 2018 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

Journal: Journal of global antimicrobial resistance
DOI: 10.1016/j.jgar.2018.05.003
Year: 2018

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