Antibiotic resistance plasmids cointegrated into a megaplasmid harboring the blaOXA-427 carbapenemase gene.

Authors: Desmet, Stefanie and Nepal, Suruchi and van Dijl, Jan Maarten and Van Ranst, Marc and Chlebowicz, Monika A and Rossen, John W and Van Houdt, Jeroen K J and Maes, Piet and Lagrou, Katrien and Bathoorn, Erik

OXA-427 is a new class D carbapenemase encountered in different species of Enterobacteriaceae in a Belgian hospital. To study the dispersal of this gene, we performed a comparative analysis of two plasmids containing the blaOXA-427 gene, isolated from a Klebsiella pneumoniae strain and an Enterobacter cloacae complex strain. The two IncA/C2 plasmids containing blaOXA-427 share the same backbone; in the K. pneumoniae strain, however, this plasmid is cointegrated into an IncFIb plasmid, forming a 321-kb megaplasmid with multiple multiresistance regions. Copyright © 2018 American Society for Microbiology.

Journal: Antimicrobial agents and chemotherapy
DOI: 10.1128/AAC.01448-17
Year: 2018

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