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Authors: Zhong, Ziming and Marcel, Thierry C and Hartmann, Fanny E and Ma, Xin and Plissonneau, Clémence and Zala, Marcello and Ducasse, Aurélie and Confais, Johann and Compain, Jérôme and Lapalu, Nicolas and Amselem, Joëlle and McDonald, Bruce A and Croll, Daniel and Palma-Guerrero, Javier

Zymoseptoria tritici is the causal agent of Septoria tritici blotch, a major pathogen of wheat globally and the most damaging pathogen of wheat in Europe. A gene-for-gene (GFG) interaction between Z. tritici and wheat cultivars carrying the Stb6 resistance gene has been postulated for many years, but the genes have not been identified. We identified AvrStb6 by combining quantitative trait locus mapping in a cross between two Swiss strains with a genome-wide association study using a natural population of c. 100 strains from France. We functionally validated AvrStb6 using ectopic transformations. AvrStb6 encodes a small, cysteine-rich, secreted protein that produces an avirulence phenotype on wheat cultivars carrying the Stb6 resistance gene. We found 16 nonsynonymous single nucleotide polymorphisms among the tested strains, indicating that AvrStb6 is evolving very rapidly. AvrStb6 is located in a highly polymorphic subtelomeric region and is surrounded by transposable elements, which may facilitate its rapid evolution to overcome Stb6 resistance. AvrStb6 is the first avirulence gene to be functionally validated in Z. tritici, contributing to our understanding of avirulence in apoplastic pathogens and the mechanisms underlying GFG interactions between Z. tritici and wheat. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

Journal: The New phytologist
DOI: 10.1111/nph.14434
Year: 2017

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