October 19, 2011

Pacific Biosciences of California, Inc. Third Quarter 2011 Earnings Conference Call

MENLO PARK, Calif., Oct. 19, 2011 (GLOBE NEWSWIRE) — Pacific Biosciences of California, Inc. (Nasdaq:PACB) will hold its quarterly conference call to discuss its Third Quarter 2011 results on Thursday, October 27, at 4:30pm Eastern Time.

The call will be webcast and may be accessed at Pacific Biosciences’ website at: http://investor.pacificbiosciences.com

Date: October 27, 2011

Time: 4:30pm ET

Listen via Internet: http://investor.pacificbiosciences.com

Toll-free: 866.831.6267

International: 617.213.8857

Password: 760 060 05

Replay: http://investor.pacificbiosciences.com

About Pacific Biosciences

Pacific Biosciences’ mission is to transform the way humankind acquires, processes and interprets data from living systems through the design, development and commercialization of innovative tools for biological research. The company has developed a novel approach to studying the synthesis and regulation of DNA, RNA and proteins. Combining recent advances in nanofabrication, biochemistry, molecular biology, surface chemistry and optics, Pacific Biosciences has created a powerful technology platform called single molecule, real-time, or SMRT®, technology. SMRT® technology enables real-time analysis of biomolecules with single molecule resolution, which has the potential to transform the understanding of biological systems by providing a window into these systems that has not previously been open for scientific study.

CONTACT: Pacific Biosciences

         Trevin Rard

         650.521.8450

         ir@pacificbiosciences.com

Source: Pacific Biosciences of California, Inc.

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