Pacific Biosciences of California, Inc. First Quarter 2011 Earnings Conference Call

MENLO PARK, Calif, April 25, 2011 (GLOBE NEWSWIRE) — Pacific Biosciences of California, Inc. (Nasdaq:PACB) will hold its quarterly conference call to discuss its First Quarter 2011 results, Wednesday, April 27, at 4:30pm Eastern Time.

The call will be webcast by GlobeNewswire and can be accessed at Pacific Biosciences’ website at: http://investor.pacificbiosciences.com/.

About Pacific Biosciences: Pacific Biosciences’ mission is to transform the way humankind acquires, processes and interprets data from living systems through the design, development and commercialization of innovative tools for biological research. The company has developed a novel approach to studying the synthesis and regulation of DNA, RNA and proteins. Combining recent advances in nanofabrication, biochemistry, molecular biology, surface chemistry and optics, Pacific Biosciences has created a powerful technology platform called single molecule, real-time, or SMRT(tm), technology. SMRT technology enables real-time analysis of biomolecules with single molecule resolution, which has the potential to transform the understanding of biological systems by providing a window into these systems that has not previously been open for scientific study.

All statements in this press release that are not historical are “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act as amended. These statements may contain words such as “believe,” “will,” “may,” “estimate,” “anticipate,” “continue,” “intend,” “expect,” “plan,” the negative of these terms, or other similar expressions. Any expectations based on these forward-looking statements are subject to risks and uncertainties and other important factors, including those discussed from time to time in documents we have filed with the Securities and Exchange Commission. Actual results may differ materially from the results expressed or implied by the forward-looking statements, and you are cautioned that forward-looking statements are not guarantees of future performance. We undertake no obligation to update these forward-looking statements over
time.

pacific biosciences

CONTACT: Pacific Biosciences

         Trevin Rard (Investor Relations)

         650.521.8450

         ir@pacificbiosciences.com

Source: Pacific Biosciences of California, Inc.

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