April 19, 2012

Pacific Biosciences of California, Inc. 1st Quarter 2012 Financial Results Call

MENLO PARK, Calif., April 18, 2012 (GLOBE NEWSWIRE) — Pacific Biosciences of California, Inc. (Nasdaq:PACB) will hold its quarterly conference call to discuss 1st Quarter 2012 financial results on Tuesday, May 1, at 4:30pm Eastern Time.

The call will be webcast and may be accessed at Pacific Biosciences’ website at: http://investor.pacificbiosciences.com/.

Date: May 1, 2012

Time: 4:30pm ET

Listen via Internet: http://investor.pacificbiosciences.com/

Toll-free: 866.783.2137

International: 857.350.1596

Password: 916.273.13

Replay: http://investor.pacificbiosciences.com

About Pacific Biosciences

Pacific Biosciences’ mission is to transform the way humankind acquires, processes and interprets data from living systems through the design, development and commercialization of innovative tools for biological research. The company has developed a novel approach to studying the synthesis and regulation of DNA, RNA and proteins. Combining recent advances in nanofabrication, biochemistry, molecular biology, surface chemistry and optics, Pacific Biosciences has created a powerful technology platform called single molecule, real-time, or SMRT®, technology. SMRT technology enables real-time analysis of biomolecules with single molecule resolution, which has the potential to transform the understanding of biological systems by providing a window into these systems that has not previously been open for scientific study.

CONTACT: Pacific Biosciences

         Trevin Rard

         650.521.8450

         ir@pacificbiosciences.com

Source: Pacific Biosciences of California, Inc.

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