Pacific Biosciences and GenDx Initiate Co-Marketing Activities for Full-Length HLA Gene Sequencing Products
Thursday, June 19, 2014
The Human Leukocyte Antigen (HLA) system consists of a large family of highly variable genes and allelic variants that forms the basis of the human immune system. High-resolution HLA typing and sequencing of the complete gene enables determination of even the smallest variations between HLA alleles. HLA allele-specific genotyping is critical for autoimmune disease-association studies, drug hypersensitivity research and other applications. Thus, there has been an ever growing interest in characterizing the HLA genes in their entirety.
GenDx, which currently offers reagents for the amplification of full-length, Class I HLA genes, will offer a version of its NGSgo® reagent line with barcoded primers developed with Pacific Biosciences for sequencing on the PacBio RS II DNA sequencing system. Using the GenDx NGSengine® software package to analyze data from the PacBio system provides customers with a highly accurate, allele-level HLA typing solution. This new reagent kit will allow the pooling of full-length, Class I HLA genes from multiple samples into a single sequencing run. More information about the new solution and ordering information can be found at https://www.gendx.com/pacbio-ngs.
“With extraordinarily long reads and industry-leading accuracy, Single Molecule, Real-time (SMRT®) Sequencing really addresses the unique needs of the HLA research community,” said
About the PacBio RS II and SMRT Sequencing
Pacific Biosciences’ SMRT Sequencing technology achieves the industry’s longest read lengths, highest consensus accuracyi,ii and the least degree of bias.iii These characteristics, combined with the ability to detect many types of DNA base modifications (e.g., methylation) as part of the sequencing process, make the PacBio RS II an essential tool for many scientists studying genetic and genomic variation. The PacBio platform provides a sequencing solution that can address a growing number of complex medical, agricultural and industrial problems.
About Pacific Biosciences
GenDx is a Dutch molecular diagnostics company that develops and markets a comprehensive line of In Vitro Diagnostic (IVD) tests and services, analysis software and education. The company is a pioneer in the area of Sequence-Based Typing (SBT) for transplantation. GenDx supports the software package SBTengine® and reagent line SBTexcellerator® for
organizing dedicated HLA-SBT training courses worldwide on a regular basis for personnel of tissue typing laboratories, blood banks and donor registries. GenDx is a trade name of
i Koren et al., “Reducing assembly complexity of microbial genomes with single-molecule sequencing.” Genome Biology, 14:R10.1 (2013).
ii Chin et al., “Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data.” Nature Methods, 10; 563-569 (2013).
iii Ross et al. Characterizing and measuring bias in sequence data. Genome Biol 14: R51 (2013).
CONTACT: For Pacific Biosciences: Media:
Nicole LitchfieldFor Pacific Biosciences 415.793.6468 email@example.com Investors: Trevin RardPacific Biosciences 650.521.8450 firstname.lastname@example.org
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