Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Leading the way into the future: HiFi whole genomes as a replacement for exome and short-read genome sequencing
For years, exome sequencing has been a popular method for identifying disease-causing variants, both in clinical and research settings, due to its relative affordability and practicality when compared to whole-genome…
TGen sees big developments coming for cancer liquid biopsy research thanks to ultra-accurate PacBio short reads
Cristian Tomasetti, PhD, discusses the positive impact of super-accurate PacBio short reads on the development of cancer early detection assays at TGen and City of Hope.
Powered by PacBio: Selected publications from February 2024
Get a quick summary of the hottest scientific articles and preprints to incorporate PacBio HiFi sequencing for the month of February 2024.
Progress report: HiFi sequencing enables Care4Rare Consortium to advance rare disease research
In honor of Rare Disease Day 2024, we spoke with Dr. Kym Boycott of the Care4Rare Consortium about how HiFi sequencing has helped deliver answers to families impacted by rare genetic diseases.
Watch: Kinnex kits enable full-length 16S and RNA sequencing at scale
When new sequencing instruments are released, great leaps in genomics capabilities follow. But did you know that for some applications like 16S microbiome research, gene annotation, or cancer transcriptomics, “new-instrument-level” performance can be achieved with something as simple as an off-the-shelf kit?
Rare disease research. Can HiFi sequencing help shorten the journey to answers?
According to the United States’ National Institutes of Health (NIH), an estimated 7,000 rare diseases collectively impact between 3.5% to 5.9% of the global population, equating to 263 to 446…
Powered by PacBio: Selected publications from January 2024
Coming to you a little late out of the gate, this edition of Powered by PacBio includes some hot publications from this past month including: a powerful new metagenome assembler, a long-read wheat pan-transcriptome, and two papers delving into cancer biology. Take a look!
2023 gene therapy research STAR Grant winners announced
In 2023, PacBio selected five up-and-coming gene therapy researchers to receive our STAR Grant award which provides sequencing assistance and a travel stipend to present a PacBio sponsored event. Check out our winners and their projects!
Winning proposals for 2023 PacBio grants announced
At PacBio we are obsessively motivated to create the most powerful long and short-read sequencing technologies in the world — so that you can shatter the status quo and forge…
Highly accurate sequencing enables the detection of microsatellite instability associated with cancer
Onso short-read sequencing systems are no longer available through PacBio In the complex landscape of cancer biology, the exploration of microsatellite instability (MSI) has emerged as a promising frontier, offering…
Mastering AAV vector design: Best practices for gene therapy product characterization using HiFi sequencing
By Claire Aldridge, PhD Dr. Aldridge, Chief Strategy Officer at Form Bio, pioneers advanced pharmaceutical solutions to get life-saving therapeutics to patients. She was recently selected as one of Forbes’…
Our favorite publications of 2023
2023 has been an incredible year for genomics! Thanks to the brilliance and scientific talent of researchers all over the world, major progress was made across the board –from agrigenomics…
High-quality genomes for a biodiverse Christmas
After last year’s humongous achievement of assembling the 100 Gb mistletoe genome, it is very exciting to see many more holiday associated species assembled by the Darwin Tree of Life…
Sequencing 101: Structural variation
Over the last 50 years, many monumental achievements in genetics and biology have unfolded before our eyes. From the invention of DNA sequencing technologies to the completion of the human…
Kinnex launch promises to revolutionize RNA research
RNA sequencing (RNA-seq) has become an indispensable tool for analyzing transcriptomes across all domains of life that can reveal insights about biology and disease. While the genome remains relatively constant…