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This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.

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Scientists Generate the First Personal Transcriptome Using SMRT Sequencing

A new paper from scientists at Stanford University and Yale University describes the use of Single Molecule, Real-Time (SMRT®) Sequencing to generate transcriptomes for three individuals. The work is believed…

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At SFAF 2014, Great Science and High-Quality Genomes

It’s been a busy start to the summer, but we’re still basking in the top-notch presentations and posters from the Sequencing, Finishing, and Analysis in the Future meeting last month….

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Unprecedented Read Length at the Icahn Institute:
Precise Sizing + SMRT Sequencing

At the Icahn Institute for Genomics and Multiscale Biology at Mount Sinai in New York City, technology development expert Robert Sebra, Ph.D., sees tremendous need for long-read, high-accuracy sequencing for…

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ARCHIVED: Intro to the Iso-Seq Method: Full-length transcript sequencing

Since the launch of the Iso-Seq protocol in SMRT Analysis in 2014, the analysis pipeline has seen several improvements, as well a host of new tools. Please see our updated…

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Research Studies Use Sequencing to Track Path of Infection Outbreaks

A talk at last week’s ASM conference continued the recent trend of scientists using Single Molecule, Real-Time (SMRT®) Sequencing in research projects designed to better understand the transmission path of…

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The Sequence Analysis Meeting: SFAF 2014

The Sequencing, Finishing, and Analysis in the Future (SFAF) meeting kicks off today in Santa Fe, New Mexico. The conference is hosted by Los Alamos National Laboratory and focuses on…

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At ASM, Pioneering Scientists Presented Bacterial Methylome Highlights

This week’s annual meeting of the American Society for Microbiology was every bit as interesting, data-rich, and jam-packed as promised. We’re grateful to everyone who stopped by our booth and…

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American Society for Microbiology (ASM) Preview –
SMRTest Microbe Grant Program

We’re getting ready for next week’s annual meeting of the American Society for Microbiology. Thousands of microbiologists from around the world will be gathering in Boston for the event, which…

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A New Approach for HLA Typing: SMRT Sequencing

Two recent news announcements demonstrate the utility of our Single Molecule, Real-Time (SMRT®) Sequencing technology in the challenging realm of HLA typing. HLA typing — or analysis of genes in…

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Retroviral Study Reveals Potential for Influencing HIV Replication

Scientists from the Icahn School of Medicine at Mount Sinai in New York City and the MRC National Institute for Medical Research in London published a paper using Single Molecule,…

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Webinar Recap: New Insights in Genome and Transcriptome Research

This week, our CSO Jonas Korlach hosted a webinar entitled “Gain New Insights in Genome and Transcriptome Research with Greater than 10,000 bp Reads.” He spoke to attendees about the…

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SMRT Sequencing of Chicken Heart Transcripts Yields New Genes and Isoforms

The Gallus gallus (common chicken) genome was initially published in 2004, but the latest RefSeq and Ensembl annotations remain incomplete. The chicken is an important model organism, especially for research…

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Innovation Centre in Quebec Uses SMRT Sequencing for
Cost-Effective, Complete Microbial Genomes

At the McGill University and Génome Québec Innovation Centre, many projects conducted in the sequencing core facility fall under the umbrella of life sciences rather than biomedical research. To the…

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Webinar Recap: Automating PacBio 10 kb template preparation

During our recent sample prep webinar, PacBio® scientists described new automated options for the 10 kb SMRTbell™ template preparation workflow. In case you didn’t have the chance to attend, here’s…

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GC-Rich Genome of Pandoraea Bacterium Assembled with SMRT Sequencing

Scientists from the Institute of Biological Sciences at the University of Malaya recently published a description of Pandoraea sp. strain RB-44 in Genome Announcements, a journal from the American Society…

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