Blog
September 20, 2016
UPDATED Data Release: Comprehensive Alzheimer Brain Isoform Sequencing (Iso-Seq) Dataset
NOTE: This blog was updated with the latest data from the Sequel II System on March 9, 2020. Alzheimer’s disease (AD) is a devastating neurodegenerative disease that affects ~44 million…
September 6, 2016
Avian Celebrity: Kākāpō Genomes Make Headlines
A recent cover story in New Zealand Geographic vividly details the efforts to sequence not just the kākāpō genome, but the genomes of every single living kākāpō. If you missed…
September 1, 2016
Network with the SMRT Sequencing Community at Our Upcoming Events
We’re lucky to have such a vibrant community of SMRT Sequencing users, and there’s nothing better than getting them together to share tips, exchange ideas, and develop new applications. These…
August 26, 2016
Scientists Turn to SMRT Sequencing to Decode Chardonnay Genome
A case study produced by QRIScloud, an Australia-based cloud computing service, offers interesting insight into a recent project that is using SMRT Sequencing to generate a reference-quality de novo genome…
August 25, 2016
Precision Medicine Review Highlights Need for Accuracy & Comprehensiveness in Genome Sequencing
Stanford’s Euan Ashley wrote a terrific review about the clinical use of genome sequencing for Nature Reviews Genetics. “Towards Precision Medicine” is well worth a read, covering topics from the…
August 2, 2016
SMRT Sequencing Accurately Detects Gene Copy Numbers in Complex Maize Genome
Scientists from Rutgers University and the University of California, Davis, used SMRT Sequencing to study structural variation in maize. They found that this approach delivered more complete information at lower…
August 1, 2016
Histogenetics Ramps Up HLA Typing with SMRT Sequencing
PacBio customer HistoGenetics was just awarded a major, multi-year contract to perform HLA typing on as many as thousands of samples per week using SMRT Sequencing. The company is a…
July 28, 2016
The Birth of a Symbiont: Epigenome Analysis Reveals Shifting Methylation Profile
A recent publication from scientists at the University of Florida and the University of Missouri used SMRT Sequencing to analyze epigenomic changes that occur when free-living bacteria associate with a…
July 26, 2016
Mitochondrial Genome Analysis Yields Novel Findings in Antiretroviral-Treated HIV Patients
Scientists from Yale University and Memorial Sloan Kettering Cancer Center used SMRT Sequencing to determine whether antiretroviral therapies were triggering mitochondrial genome mutations in HIV patients. The results were recently…
July 11, 2016
First Comprehensive View of Alternative Splicing in Sorghum Powered by SMRT Sequencing
A paper from scientists at Colorado State University and the National Center for Genome Resources provides an in-depth view of the transcriptome of sorghum, a crop that’s important for human…
July 6, 2016
In Chinese Genome Assembly, SMRT Sequencing Finds Novel Genes and Recovers Missing Sequence
A paper just out in Nature Communications reports the de novo genome assembly and transcriptome of a Chinese individual, generated from long-read SMRT Sequencing and other technologies. The effort revealed…
June 24, 2016
Iso-Seq Study Reveals More Complexity than Expected in Maize Transcriptome
In a new publication from Cold Spring Harbor Laboratory, scientists produced a dataset for what authors call “the single largest collection of [full-length] cDNAs available in maize” and significantly improved…
June 23, 2016
Data Release: Zika-Susceptible Aedes aegypti De Novo Genome Assembly
We are excited about the release of a new genome assembly for the mosquito Aedes aegypti, which we hope will aid scientists in studying vector-pathogen dynamics, including those of the…
June 22, 2016
East Coast UGM: SMRT Sequencing Data for Carnivorous Plants, Hummingbirds, Mammalian Methylation, Repeat Expansions, and More
Many thanks to the nearly 200 scientists who signed up for our East Coast User Group Meeting, and to the Institute for Genome Sciences for hosting us! The event was a…
June 15, 2016
SMRTest Microbe Grant Program:
Nominate Your Favorite Microbe Now!
We’re pleased to launch the latest opportunity to have your favorite microbe sequenced on a PacBio System. The SMRTest Microbe Grant Program, kicking off at this year’s American Society for…