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This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.

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At CROPS 2017, SMRT Sequencing Powers Reference Plant Genome Assemblies

This week the HudsonAlpha Institute for Biotechnology and the University of Georgia are co-hosting CROPS 2017, a meeting focused on genomic technologies and their use in crop improvement and breeding…

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In Texas, New View of Klebsiella Strain Diversity and Antibiotic Resistance

A sweeping new report on Klebsiella pneumoniae sequence data from scientists at the Houston Methodist Research Institute, Weill Cornell Medical College, and other institutions found more diversity than expected in strains…

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At ASM Microbe 2017, SMRT Sequencing Advances Microbial Applications

We can’t wait for ASM Microbe! It’s one of the largest microbiology conferences in the world and is taking place June 1-5 in New Orleans. With more than 10,000 people…

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Genome Assembly Advances Featured in Genome Research Special Issue

The May issue of Genome Research is a special edition focusing on advances in sequencing technologies and genome assembly techniques. The research papers selected for this special issue cover reference-grade…

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TB Study Finds Some Previously Reported Virulence Variants Were Sequencing Errors

A publication in BMC Genomics upends some of the conventional wisdom about variants that may cause virulence in Mycobacterium tuberculosis. Scientists at San Diego State University used SMRT Sequencing to…

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New Iso-Seq Chicken Analysis Finds Missing Genes and Transcript Complexity

A new publication in BMC Genomics explores the use of RNA normalization and 5’ cap selection to enhance results from Iso-Seq studies using SMRT Sequencing. Scientists from the University of…

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SMRT Sequencing Enables Accurate Calling of Pathogenic Variants in Medically Relevant Genes

Screening for pathogenic variants associated with polycystic kidney disease is now more accurate and affordable with SMRT Sequencing. A new paper in Human Mutation from scientists at Leiden University Medical…

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Happy DNA Day! A Celebration of Great Science

It’s DNA Day, the annual celebration of the discovery of the double helix, the completion of the Human Genome Project, and all things genetic. We like to take the opportunity…

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On Earth Day, a Shout Out to the Conservation Genomics Community

Today is Earth Day, a great time to reflect on the growing trend of conversation genomics. We are proud that many scientists are using PacBio long-read sequencing for the goal…

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Review Paper Showcases Clinical Applications for SMRT Sequencing

Researchers from the Okinawa Institute of Advanced Sciences published a compelling review article describing several recent clinically relevant projects they have completed using SMRT Sequencing. Released in the journal Human…

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New QC pipeline for Iso-Seq data increases confidence in transcript results

A preprint from scientists at the University of Florida, Centro de Investigaciones Principe Felipe, and other institutes describes a new analysis tool to help boost quality of transcriptome studies. “SQANTI:…

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Crow Genome Analysis Combines Assemblies to Spot Tandem Arrays

A new publication in Genome Research shows how the use of SMRT Sequencing, in combination with other technologies, can reveal far more about repetitive DNA and structural variants than short-read…

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Network with the SMRT Community at Our Upcoming User Group Meetings & Events

We are excited to announce our 2017 series of SMRT Community Events and User Group Meetings (UGMs), where you can learn first-hand how members of the scientific community are leveraging…

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At AACR, Revealing Structural Variants and a New SMRT Grant Program

We’re excited to be heading to Washington, DC, for the annual meeting of the American Association for Cancer Research. The PacBio team always enjoys hearing about the latest in cancer…

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IGV 3 Improves Support for PacBio Long Reads

The recent beta release of version 3 of the popular genome browser IGV greatly improves support for PacBio data [1]. The long reads (up to 50 kb) and random error…

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