Blog
August 9, 2017
Iso-Seq Analysis Reveals Differential Expression in Male and Female Abalones
Earlier this year, scientists from Korea reported results from a transcriptome study of Pacific abalone. In this paper, the team used SMRT Sequencing to demonstrate that alternative splicing and gene…
August 7, 2017
SMRT Sequencing Shines at ISAG: First Sequel System Bovine Genome Presented
If you weren’t at the 36th International Society for Animal Genetics Conference in Dublin, you missed more than a chance to drink Guinness and practice an Irish brogue. The PacBio…
August 3, 2017
At Baltimore UGM, New Tools and Research Breakthroughs with SMRT Sequencing
We were delighted to be back at the University of Maryland this summer for our annual East Coast User Group Meeting. The day-long event, preceded by half-day workshops on sample…
August 1, 2017
To Resolve KIR Region, Scientists Pair SMRT Sequencing with Fosmid Cloning
A paper from scientists at the National Marrow Donor Program, Center for International Blood and Marrow Transplant Research, Fred Hutchinson Cancer Research Center, and other institutions reports the use of…
July 27, 2017
At SMBE 2017, SMRT Sequencing Fuels Genome Assemblies for Evolution Studies
We enjoyed attending the annual meeting of the Society for Molecular Biology and Evolution in Austin earlier this month. Some 1,500 people attend SMBE, which this year offered cutting-edge sessions…
July 20, 2017
‘A Quiet Revolution’: SMRT Sequencing Powers Increasing Genome Assembly Quality
A news article in Science magazine nicely captures the improvements in the quality of genome assemblies made possible by long-read sequencing and other methods. “New technologies boost genome quality” was…
July 19, 2017
New Assembly for Complex Bread Wheat Genome: 10 Times Higher Contiguity
UPDATE: This preprint is now published! Check it out in the November 2017 issue of GigaScience. In a new bioRxiv preprint, scientists from Johns Hopkins present a major step forward…
July 18, 2017
Novogene to Build Database of Structural Variants in 1,000 Chinese Genomes Using SMRT Sequencing
In an effort to improve precision medicine in Chinese populations, Novogene announced plans to build a database of structural variants in 1,000 Chinese individuals using PacBio SMRT Sequencing. Databases which…
July 11, 2017
Population Genomics Study Shows Faster Evolution in Domesticated Yeast
In a Nature Genetics paper, scientists used SMRT Sequencing to detect and compare structural variations in several yeast strains in order to understand evolutionary genome dynamics. They found different rates…
July 6, 2017
For High-Quality Ant Genomes, Scientific Alliance Chooses SMRT Sequencing
The Global Ant Genomics Alliance (GAGA) recently announced that it has adopted SMRT Sequencing as its technology of choice for generating high-quality genome assemblies. The alliance, made up of more…
June 29, 2017
Study Used Iso-Seq Method to Unravel Activity of Receptors in Prostate Cancer
A new publication in Clinical Cancer Research from scientists at the Mayo Clinic, University of Minnesota, and other institutions presents results from a study to evaluate androgen receptor (AR) isoforms…
June 27, 2017
Iso-Seq Data Supports Annotation Efforts for Key Crops Wheat and Barley
Two recent papers underscore the importance of using PacBio full-length RNA sequencing to interrogate transcriptomes for major crops. Together, these publications offer compelling evidence that information considered essential for crop…
June 22, 2017
Stanford Scientists Report First Use of PacBio Whole Genome Sequencing to Identify a Disease-Causing Mutation
An article published today in Genetics in Medicine from Jason Merker, Euan Ashley, and colleagues at Stanford University reports the first successful application of PacBio whole genome sequencing to identify a…
June 19, 2017
At SMRT Leiden, Improvements in Characterizing Genomes, Transcriptomes, and Methylomes
Last month, we co-hosted the 2nd annual SMRT Leiden conference with Leiden University Medical Center. SMRT Leiden featured three days of excellent presentations, including one day focused on bioinformatics. If…
June 13, 2017
New Maize Reference Genome Will Support Crop Improvement Programs
A large group of scientists published a new reference genome assembly for maize. It was generated with SMRT Sequencing and other technologies, and represents a major leap forward in accurately…