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This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.

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How to Incorporate New Features into Your Sequencing Services Menu

Many people who run a sequencing core lab would prefer to focus on science instead of business, but all core lab managers know that it’s imperative to keep a steady…

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New Look at Breast Cancer Cell Line Sheds Light on Structural Complexity

In an exciting paper that made the cover of Genome Research, scientists from Cold Spring Harbor Laboratory and collaborating institutions report the genome sequence and transcriptome of a commonly used…

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Webinar Summary: Developing Benchmark Sets for Structural Variants

A map of every individual’s genome will soon be possible, but how will we know if it is correct? Benchmarks are needed in order to check the performance of sequencing,…

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International Eagle Conservation Efforts Bolstered By New Genome Release

Genetics is not only key to discovering and tracing new traits in an organism, but also conserving old ones — and in some cases, the species itself. A deep understanding…

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PacBio Sequencing Reveals Food Processing & Pathogenic Strains of Yeast are the Same Species

What’s in a name? Too much, when it comes to the taxology of yeast, it turns out. Scientists from University College of Dublin have found that two distinctly named species…

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Something to Crow About: SMRT Sequencing Aids Conservation of Rare Hawaiian Bird

Brought to the brink of extinction, the future of Hawaii’s only lineage of the crow family (Corvidae) is looking up thanks to intensive conservation genomics efforts using PacBio de novo…

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Diversity of Unexpected CRISPR Edits Revealed by SMRT Sequencing

A new Nature Biotechnology publication is sending reverberations through the CRISPR and gene therapy communities. The discovery that the widely used CRISPR/Cas9 method results in far more genomic changes than…

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Deep Dives into DNA of Marine Biology

“Live every week like it’s Shark Week,” 30 Rock character Tracy Jordan once quipped to Kenneth the Page, referencing the week-long, dorsal-finned programming phenomenon that has become the Discovery Channel…

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SMRT Science, Tips & Tricks Presented at Leiden Meeting

When was the last time you sent your DNA off to a day at the spa? Olga Pettersson of the SciLifeLab at Uppsala University lets her molecules relax for up…

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Long Look Into Ant Brains Provides Epigenetic Insights

To understand the epigenetic regulation of brain function and behavior, scientists are turning to ants. To understand the ants, they are applying the accurate, long reads of SMRT Sequencing. While…

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Egyptian Rousette Bat Genome Provides Clues to Antiviral Mystery

When humans are infected with the Marburg virus, the result is often lethal, with hemorrhagic fever and other symptoms similar to Ebola. When bats are infected, the result is…. nothing….

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Maize Collaborators Embark on Ambitious 26-line Pangenome Project

The first reference genome for maize variety B73, completed in 2009, was a major milestone, and an improved version released by Cold Spring Harbor Laboratory scientists in 2017 provided a…

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One Million Genomes Meeting Discusses Progress and Promise of Population-Scale Genomics

The PacBio team was honored to attend an excellent Keystone Symposium in Hannover, Germany recently. The event, “One Million Genomes: From Discovery to Health,” offered a rare look at…

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Plant and Animal SMRT Grant Will Enable Insight Into Sightless Fish

When German diver Joachim Kreiselmaier reached the deepest parts of the Danube-Aach cave system, he couldn’t believe his eyes: a “strange fish,” with a pale body coloration and smaller eyes…

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It’s a Small World After All at ASM Microbe 2018

When it comes to bacteria, resistance is not always futile, or so we learned at the annual meeting of the American Society for Microbiology. One of our favorite events of…

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