SPRQ-Nx CHEMISTRY APPLICATION BRIEF
HiFi long-read sequencing for $345 per genome
SPRQ-Nx chemistry with multi-use SMRT Cells reduce your cost per HiFi whole genome by ~30% — with no changes to library prep, hardware, or analysis pipelines.
>90%
bases Q30+
(Avg ~16 kb read length)
99.88%
SNV accuracy (F1)
2,500+
genomes per Revio system in a year
Access your app brief
Project cost calculator, competitor comparison, and new SPRQ-Nx chemistry data – all in one document.
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THE EVIDENCE
Beta Results and Data Quality
Identical variant detection accuracy between SMRT Cell uses — validated by beta customers and HG002 benchmarking.
Every run includes epigenetics
5mC + 6mA + 5hmC detection included in every HiFi run. No bisulfite conversion, no additional library prep, no extra cost.
THE ECONOMICS
How SPRQ-Nx cuts your cost
SPRQ-Nx chemistry enables SMRT Cell multi-use on the Revio system — running multiple acquisitions on a single cell. Save ~30% on reagent costs with no changes to library prep, hardware, or pipelines.
$345
per genome
HiFi long-read WGS
Complete whole genomes with multi-use SMRT Cells — approaching short-read economics with more biological insight.
30%
Cost reduction with SPRQ-Nx
Consumable cost per genome reduced by approximately one-third. Equivalent data quality on each use.
Zero
new steps required
Same library prep. Same hardware. Same pipelines. Automated, on-instrument washcycle (10-15 min) between uses.
See the full value of SPRQ-Nx
Project cost calculator, competitor comparison, and new SPRQ-Nx chemistry data – all in one document.
Pacific Biosciences of California, Inc. — 1305 O’Brien Dr., Menlo Park, CA 94025 Research use only. Not for use in diagnostic procedures. © 2026 PacBio. All rights reserved. Legal + trademarks and privacy policy.
