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Case study: SMRT sequencing brings clarity to HIV vaccine and transplant research at the Wisconsin national primate research center.

2017

Summary +

The Wisconsin National Primate Research Center (WNPRC) is a leading Major Histocompatibility Complex (MHC) typing lab that focuses on monkeys. While many scientists are familiar with the importance of characterizing the histocompatibility region of the human genome for applications like disease research or tissue typing before organ transplantation, fewer are aware of the need to accurately type this region in non-human primates. At the primate research lab, part of the University of Wisconsin- Madison, scientists are analyzing immune regions to help test potential HIV vaccines and AIDS therapies. Their work is essential for understanding the effects of treatment ahead of human trials.

Plant and Animal Sciences Brochure: A comprehensive view of genetic diversity.

2017

Summary +

Single Molecule, Real-Time (SMRT®) Sequencing combines long reads with uniform coverage to provide uniquely comprehensive views of plant and animal genomes and transcriptomes. High-quality genome assemblies and evidence-based annotations promote improved genetic marker development, discovery of novel genes, and structural variation characterization.

Application Brief: Low-coverage, long-read whole genome sequencing for structural variation – Best Practices.

2017

Summary +

With the Sequel System, you can affordably and sensitively characterize structural variation (SV) of all types ranging in size from tens to thousands of basepairs. Low-coverage, long-read whole genome sequencing (WGS) data provides rapid discovery of common SVs for population genetics studies and resolves rare SVs unique to an individual, with a very low false-discovery rate.

Application Brochure Microbial Communities: Complex microbial populations simplified.

2017

Summary +

The ability to identify and understand the functions of the complex microbial populations living in, on, and around us requires comprehensive characterization of each community member. Long reads, high accuracy, and single-molecule resolution make Single Molecule, Real-Time (SMRT) Sequencing ideal for full-length 16S rRNA sequencing, long-read metagenomic profiling, and shotgun metagenomic assembly.

Cancer Brochure: Discover the hidden landscape of cancer variants

2017

Summary +

To bring precision medicine to every patient, cancer researchers need a more comprehensive view of all the somatic variants in genes, transcripts and whole genomes that drive cancer biology. Single Molecule, Real-Time (SMRT) Sequencing delivers the read lengths, uniform coverage, and accuracy needed to access the complete size spectrum of driver mutations — from rare single nucleotide variants to complex structural variants. Full-length transcript sequencing brings clarity to tumor-specific isoform and splice variant expression, enabling the discovery of novel biomarkers for early detection, tumor stratification, treatment response, and drug resistance. With SMRT Sequencing, scientists gain new insight into the most pressing questions in cancer research.

Core Lab Brochure: The most trusted long-read technology

2017

Summary +

SMRT Sequencing Is Smart Business: Scientists are relying on long-read sequencing for generating high-quality reference genomes, more accurate gene and transcript models, and an integrated view of the epigenome for their organisms of interest. Single Molecule, Real-Time (SMRT) Sequencing from PacBio is the most established and trusted long-read sequencing solution available today, delivering the most complete genomic information for microbes, complex plant and animal genomes, and human biomedical research challenges. Sequencing providers are rapidly adding SMRT Sequencing to their portfolios in order to meet their customers’ demand for long reads.

Human Biomedical Research Brochure: The most comprehensive view of the human genome

2017

Summary +

To understand the genetic factors underlying health and disease and to address hidden heritability, scientists require a more comprehensive view of all the variations in the human genome. Single Molecule, Real-Time (SMRT) Sequencing delivers the read lengths, uniform coverage, and accuracy needed for accessing the complete size spectrum of sequence variant types — from single nucleotides to complex structural variants. PacBio’s long single-molecule reads also provide direct variant phasing information across full-length genes and chromosome haplotype blocks. With SMRT Sequencing, scientists gain new insight into the genetic basis of health and disease.

Case Study: Improving precision medicine studies in Asia using ethnicity-specific human reference genomes and PacBio long-read sequencing.

2017

Summary +

Several new high-quality human genome assemblies produce ethnicity-specific reference sequences and show how scientists can use this genetic information to improve precision medicine studies in Asian sub- populations. These projects demonstrate how long- read SMRT Sequencing provides robust detection of polymorphic structural variants in clinically relevant gene coding regions and phases variants into haplotypes.

Application Brief: Long-read RNA sequencing – Best Practices.

2017

Summary +

With Single Molecule, Real-Time (SMRT) Sequencing and the Sequel System, you can easily and affordably sequence transcript isoforms of up to 10 kb in their entirety. The lso-Seq method allows users to generate full-length cDNA sequences — with no assembly required — in order to confidently characterize the full complement of transcript isoforms within targeted genes, or across an entire transcriptome.

SMRT Analysis Brochure: Gain a deeper understanding of your sequencing data

2017

Summary +

The PacBio Platform includes an extensive software portfolio that employs key advantages of SMRT (Single Molecule, Real-Time) Sequencing technology: extraordinarily long reads, highest consensus accuracy, uniform coverage and simultaneous epigenetic characterization. Core elements of our analytical portfolio include SMRT Analysis software, DevNet and SMRT Compatible products.

Event

Dutch Society of Human Genetics Meeting (NVHG) 2017

September 21 - September 22, 2017

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