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Case Study: Improving precision medicine studies in Asia using ethnicity-specific human reference genomes and PacBio long-read sequencing

2017

Summary +

Several new high-quality human genome assemblies produce ethnicity-specific reference sequences and show how scientists can use this genetic information to improve precision medicine studies in Asian sub- populations. These projects demonstrate how long- read SMRT Sequencing provides robust detection of polymorphic structural variants in clinically relevant gene coding regions and phases variants into haplotypes.

Application Brief: Long-read RNA sequencing – Best Practices

2017

Summary +

With Single Molecule, Real-Time (SMRT) Sequencing and the Sequel System, you can easily and affordably sequence transcript isoforms of up to 10 kb in their entirety. The lso-Seq method allows users to generate full-length cDNA sequences — with no assembly required — in order to confidently characterize the full complement of transcript isoforms within targeted genes, or across an entire trenscriptome.

SMRT Analysis Brochure: Gain a deeper understanding of your sequencing data

2017

Summary +

The PacBio Platform includes an extensive software portfolio that employs key advantages of SMRT (Single Molecule, Real-Time) Sequencing technology: extraordinarily long reads, highest consensus accuracy, uniform coverage and simultaneous epigenetic characterization. Core elements of our analytical portfolio include SMRT Analysis software, DevNet and SMRT Compatible products.

Isoform Sequencing Application Brochure: Read full-length transcripts – no assembly required

2016

Summary +

The Iso-Seq method provides full-length cDNA sequences from the 5’ end of transcripts to their poly-A tails - eliminating the need for transcript reconstruction and inference - giving complete, unambiguous information about alternatively spliced exons, transcriptional start sites, and poly-adenylation sites. Confidently characterize the full complement of isoforms within targeted genes, or across an entire transcriptome.

Industrial Biotechnology Brochure: Fuel biotech discovery with confident characterization of microbes and their communities

2016

Summary +

Industrial microbiologists rely on comprehensive genomic information to identify and develop complex biological products. Single Molecule, Real-Time (SMRT) Sequencing delivers a more complete view of individual organisms and microbial communities, fueling research for modern pharmaceutical discovery, environmental remediation, chemical commodity production, and agriculture products.

Microbial Communities Application Brochure: Complex microbial populations simplified

2016

Summary +

The ability to identify and understand the functions of the complex microbial populations living in, on, and around us requires comprehensive characterization of each community member. Long reads, high accuracy, and single-molecule resolution make Single Molecule, Real-Time (SMRT) Sequencing ideal for full-length 16S sequencing, long-read metagenomic profiling, and shotgun metagenomic assembly.