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Pacific Biosciences is committed to providing high-quality products that meet customer expectations and comply with regulations. We will achieve these goals by adhering to and maintaining an effective quality-management system designed to ensure product quality, performance, and safety.

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Getting the Complete Picture

Protecting global health is best accomplished through comprehensive surveillance, complete genomic information, and accurate tracking. Tremendous progress has been made since technology first enabled the routine sequencing of pathogenic microbes.

Build a more comprehensive genomic view of microbial pathogens

The advent of Single Molecule, Real-Time (SMRT) Sequencing has radically increased the understanding of microbial genomics, pathogenicity, and antimicrobial resistance. The PacBio Systems deliver the most comprehensive genetic information available, and with SMRT Sequencing, federal agencies, healthcare centers, and other public health organizations have the ability to:

  • Generate complete genome assemblies and gain a deeper understanding of community-acquired and hospital associated infections and transmission.
  • Use microbial epigenetics to further characterize global outbreaks, pandemics, and epidemics.
  • Inform local and global preparedness and response to seasonal and annual infections by rapidly resolving viral populations.
  • Characterize complex populations to support surveillance and tracking of foodborne pathogens.

Spotlight: Long-reads shed light on the genetics of antibiotic resistance

Scientists interrogated the mobilome of drug resistant bacteria to understand their capacity for adaptation. This research showed that replicative transposons and homologous recombination are driving forces in rearrangements and evolution of resistance plasmids. Explore this research further:

He, S. et al., 2016. Mechanisms of evolution in high-consequence drug resistance plasmids. mBio, 7(6), pp.e01987–16.

Spotlight: Exploring antifungal resistance in sequential human isolates

Long-read sequencing enabled scientists to uncover 100 adhesin-like genes in Candida glabrate isolated from an HIV-positive patient. A broader understanding of adhesin biology will aid in combating the increased virulence of this fungal pathogen. Explore this research further.

Vale-Silva, L.A. et al., 2017. Comparative genomics of two sequential Candida glabrata clinical isolates. bioRxiv, Preprint.

To find out how SMRT Sequencing can advance your public health research, contact us.

Selected Resources