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Focus in, discover more

Accurately map microbial variation by focusing on specific regions of the genome while maintaining complete and uniform coverage.

Confident identifications with a complete view of variation

Polymorphisms can take the form of structural variation within a genome or its mobile elements, and must be clearly defined for the most confident and accurate conclusions. Single Molecule, Real-Time (SMRT) Sequencing provides the read length needed to clearly resolve structural variants within specific regions of interest in their genomic context. Additionally, SMRT Sequencing allows for the identification of individual members of complex microbial populations — including 16S rRNA species-level identification — and the resolution of complete plasmids or viral quasispecies.

This technology advances your microbial and viral research through the ability to:

  • Resolve complex populations in viral or metagenomic samples
  • Map order and orientation of multiply-inserted phage elements
  • Target regions in host organisms to study viral integration and integration sites
  • Phase variations across targeted regions
  • Perform multiplexed multi-locus sequence typing (MLST)

Workflow: from targeted region to accurate variant or haplotype

Spotlight: Long reads elucidate HIV envelope variants susceptible to antibody targeting

Caskey and coworkers used targeted SMRT Sequencing to determine that pre-existing variants in the HIV envelope may confer resistance to antibodies. Explore this research further:

Caskey, M. et al., 2017. Antibody 10-1074 suppresses viremia in HIV-1-infected individuals. Nature Medicine, ePub Ahead of Print.

To learn more about obtaining a complete view of microbial variation, contact us.

Selected Resources