Monday, April 30, 2018

An Interview with Baylor’s Fritz Sedlazeck on New Long-Read Algorithms

[caption id="attachment_25359" align="alignright" width="300"] Fritz Sedlazeck[/caption] Nature Methods just published “Accurate detection of complex structural variations using single-molecule sequencing,” a publication that presents the NGMLR aligner and Sniffles structural variant caller, both designed for use with long-read sequencing data. We chatted with developer and lead author Fritz Sedlazeck from the Human Genome Sequencing Center at Baylor to learn more. Q: Why was a new alignment tool needed when many scientists already use BWA and other methods? A: When I started my postdoc in Mike Schatz’s lab at Cold Spring Harbor, I had the opportunity to look at the complex SK-BR-3…

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