Tuesday, December 17, 2019

SMRT Sequencing Enables Discovery of Epigenetic Driver of C. diff Persistence

How do pernicious pathogens like Clostridioides difficile spread through hospitals and persist so tenaciously in the human gut, leading to about half a million infections and 30,000 deaths each year?  It’s a mystery scientists have been anxious to solve, and they’ve invested countless hours of research into the bacteria’s physiology, genetics and genomic evolution.   A team from Mount Sinai School of Medicine in New York City has uncovered an important new clue by studying an overlooked aspect of C. difficile’s biology: Epigenetics.  Using PacBio SMRT Sequencing and comparative epigenomics, Pedro H. Oliveira (@pholive81), Gang Fang (@iamfanggang), and colleagues mapped and…

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