Thursday, March 15, 2018

Study: SMRT Sequencing Can Improve the Safety of Gene Therapy Protocols

A new publication in the journal of the American Society of Gene & Cell Therapy demonstrates the novel use of SMRT Sequencing for improving the safety and quality of a type of gene therapy delivered through a viral vector. The work established new quality control standards and revealed previously undetected risks for gene therapy delivery. “Adeno-Associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras,” published in Molecular Therapy — Methods & Clinical Development, comes from lead author Phillip Tai, senior author Guangping Gao, and collaborators from the University of Massachusetts Medical School and other institutions.…

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