Monday, May 14, 2018

Codfish Study Employs Target Capture and SMRT Sequencing to Explore Evolution

Many investigators rely on targeted sequencing approaches for deep dives into genomic regions of interest. By designing specific probes -- often using short-read sequences directed towards the exome and supported by existing reference genomes or transcriptome assemblies -- scientists can home in on exactly the area they want to explore. But what about sequences in intergenic regions not covered by short reads, which could contain crucial regulatory elements varying between populations that might be of functional and evolutionary importance? Or, what about species lacking high-quality reference genomes to guide probe design? A team of Norwegian researchers are tackling these challenges…

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