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さらに完全な遺伝多様性の像を提供

生物学的形質に関与する遺伝的背景を理解することは、農業、産業、環境における課題解決に欠かせません。

PacBioの1分子リアルタイム(SMRT)シークエンスは大きく複雑な動植物ゲノムに遺伝多様性の完全な像をもたらし、進化研究および農業ゲノムにおいて理想的なツールです。この技術はこれまで農作物、家畜、産業製品の改善をサポートする価値のある洞察を数多くもたらしました。

PacBioシステムは幅広いアプリケーションを可能にします。

02_AgBioSpot01

高解像度に進化と多様性の探索

これまで、生物種、属、科における断片化されたリファレンスゲノムのみが存在し、探索の可能性を妨げていました。ショートリードでバイアスのある次世代シークエンサーのリードは、満足するドラフトゲノムのクオリティーを達することはできませんでした。PacBioロングリードではエビデンスに基づく遺伝子アノテーションをもつ高品質なリファレンスゲノムを構築し、最も完全な遺伝多様性の像を捉えることで、新しく意味のある探索を後押しします。

02_AgBioSpot02

農業産物改善のために鍵となる遺伝子を解明

疾患の予防と治療、あるいは害虫からの防御など農作物あるいは家畜の育種において遺伝的要素を深く理解することは重要です。PacBioの高スループットロングリードソリューションはコスト効率の良いシークエンスを可能にし、興味のある遺伝子において最も包括的で高精度な像を捉え、市場の需要に迅速に対応することができます。

02_AgBioSpot03

産業アプリケーションで高精度に生物種をエンジニアリング

既存の生化学パスウェイの最適化やエンジニアにより、微生物や植物を安全なものに変えることができます。SMRTシークエンスは各生物種あるいは微生物集団においてスムーズなシークエンスを行い、エンジニアリングの基礎となる完全かつ高精度のゲノムアセンブルをもたらします。

SMRTシークエンスProject Calculators

興味のある動植物ゲノムについて情報を入力すれば、PacBio Sequelシステムを使った下記の解析に必要な材料、時間の予測結果をご提供します。

スポットライト:ギャップをクローズして研究を前進

PacBioシークエンスが向上する動植物ゲノム研究について、Scienceで特集記事が組まれました。

Pennisi, E., 2017. New technologies boost genome quality. Science. Jul 7;357(6346):10-11.

SMRTシークエンスでどのように動植物ゲノム研究を前進させるか、ぜひお問い合わせください。

Selected Resources