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お問い合わせ

完全な像を手にする

包括的な調査、完全なゲノム解読、そして高精度なトラッキングがグローバルヘルスを守ります。病原体微生物のルーチンなチークエンス技術が応用されてから、大きな進歩が遂げられています。

微生物病原性における包括的なゲノム像を構築

PacBioの1分子リアルタイム(SMRT)シークエンスの進化により、微生物ゲノム、病菌性および抗菌性耐性における理解は飛躍的に向上しました。もっとも包括的な遺伝情報をもたらすPacBioシステムとSMRTシークエンスを組み合わせることで、連邦政府関係機関、ヘルスケアセンター、その他の公衆衛生機関では下記の解析が可能です。

  • 完全なゲノムアセンブリ解読により病院およびコミュニティに関連する感染と伝播をさらに理解
  • 微生物エピジェネティクス情報を使いグローバルなアウトブレイク、流行、伝染病の特徴づけ
  • ウィルス集団を迅速に解明し、現地およびグローバルにおける季節および年ごとの感染症準備と対策
  • 複雑な生物集団の特徴づけで食品由来病原性の調査とトラッキングをサポート

スポットライト:ロオングリードが抗生物質耐性遺伝学に光をもたらす

薬剤耐性微生物の移動因子を調査し、適応能力への理解を深めたこの論文では、複製トランスポゾンと相同性組換えが耐性プラズミドの再構成と進化をもたらしていると報告しています。

He, S. et al., 2016. Mechanisms of evolution in high-consequence drug resistance plasmids. mBio, 7(6), pp.e01987–16.

スポットライト:ヒトから単離された抗菌耐性における探索

HIV陽性患者から単離したCandida glabrateにおいて、ロングリードで100ものadhesin-like遺伝子を発見。付着因子の生物学的理解が、この菌の増加する病原性への対応の鍵を握ります。

Vale-Silva, L.A. et al., 2017. Comparative genomics of two sequential Candida glabrata clinical isolates. bioRxiv, Preprint.

SMRTシークエンスがどのように公衆衛生研究をサポートするか、ぜひお問い合わせください。

Selected Resources