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基于探针杂交的靶向富集

 

  • 1000倍富集
  • 全基因捕获 – 外显子和内含子区域
  • 变异定相,以获得单体型


基于液相捕获系统的靶向富集能够富集长达数Mb的感兴趣区域。罗氏NimbleGen的SeqCap EZ富集技术与PacBio的SMRT测序相结合,经验证可使用6 kb的片段,几乎适用于任何类型的SeqCap EZ panel。我们已经验证了主要组织相容性复合物(MHC)和全面的癌基因panel的高效富集。平均而言,所得61%的序列是命中的,且平均富集因子是1300倍。有了PacBio长读取序列,可利用杂合SNP对序列定相,并产生单体型。这份应用指南介绍了结果,并提供实验方法作为支持方案


若有意了解如何运用我们的SMRT消耗品来支持您的研究,请联系我们