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通往生物学新发现之路

表观遗传修饰广泛影响包括基因表达、宿主与病原体的相互作用、环境响应、DNA损伤和DNA修复在内的生物过程1。表观遗传学也在一代又一代的性状遗传上发挥重要作用。尽管目前已鉴定出20多种表观遗传和DNA损伤修饰,但大多数科学家仍然只能研究胞嘧啶甲基化这一种类型,还是利用间接的检测方法。直接检测这些修饰的能力对于了解DNA修饰对各种自然过程和疾病反应的影响至关重要。

基因组的表观遗传表征

单分子实时(SMRT)测序通过测定碱基掺入时的动力学变化,可直接检测表观遗传修饰。这种方法在获取序列数据的同时捕获这些修饰,也就无需特殊的样本制备和额外测序。

 

PacBio系统带您直接查看表观遗传修饰

SMRT测序检测到的主要表观遗传修饰

 

Epigenetics.Spotlight.Epigenetic-Modifications-Image

若有意了解SMRT测序如何同时捕获基因组和表观遗传信息,请联系我们

 

Reference

  1. Davis, B. M., et al., (2013) Entering the era of bacterial epigenomics with single molecule real time DNA sequencing. Current Opinion in Microbiology. 16 (2), 192–198.

Selected Resources